Display options
Cite
Di Tommaso L, Roncalli M. Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How. Front Med (Lausanne). 2017;4:10doi: 10.3389/fmed.2017.00010.
Di Tommaso, L., & Roncalli, M. (2017). Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How. Frontiers in medicine, 410. https://doi.org/10.3389/fmed.2017.00010
Di Tommaso, Luca, and Roncalli, Massimo. "Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How." Frontiers in medicine vol. 4 (2017): 10. doi: https://doi.org/10.3389/fmed.2017.00010
Di Tommaso L, Roncalli M. Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How. Front Med (Lausanne). 2017 Feb 23;4:10. doi: 10.3389/fmed.2017.00010. eCollection 2017. PMID: 28280721; PMCID: PMC5322593.
Copy Download .nbib Format: NLM
Share it on

Front Med (Lausanne). 2017 Feb 23;4:10. doi: 10.3389/fmed.2017.00010. eCollection 2017.

Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How.

Frontiers in medicine

Luca Di Tommaso, Massimo Roncalli

Affiliations

  1. Pathology Unit, Humanitas Clinical and Research Center , Rozzano, Milan , Italy.
  2. Department of Biomedical Sciences, Humanitas University , Rozzano, Milan , Italy.

PMID: 28280721 PMCID: PMC5322593 DOI: 10.3389/fmed.2017.00010

Abstract

Few tissue markers are currently available to pathologists in the study of hepatocellular tumors. These markers should be used carefully taking into consideration not only morphology but also, and sometimes even more important, the clinical setting where the lesion to be diagnosed had developed. Glypican-3, heat shock protein 70, and glutamine synthetase (GS) are markers currently used, as a single panel, to discriminate the nature of a <2 cm hepatocellular lesion lacking radiological features of hepatocellular carcinoma (HCC) detected in a cirrhotic patient under surveillance. Their use, which can be improved by clathrin heavy chain, is mostly requested on liver biopsy. Hepatocyte paraffin 1, arginase-1, polyclonal carcinoembryonic antigen, CD10, and bile salt export pump are tissue markers used to confirm, at histology, the diagnosis of HCC made by imaging before enrollment for phase III studies on novel anti-HCC drugs. In this setting, pathologists are usually requested a conclusive diagnosis on a liver biopsy of a poorly differentiated, necrotic, enriched in stem-phenotype, carcinoma. Liver fatty acid-binding protein, serum amyloid A, C-reactive protein, prostaglandin D2 synthetase, GS, and β-catenin can be used either on biopsy or surgical specimen to classify hepatocellular adenoma into hepatocyte nuclear factor (HNF-1α) inactivated (steatotic), inflammatory, with dysregulation of sonic hedgehog and prostaglandin pathways, β-catenin mutated, and unclassified.

Keywords: hepatocellular adenoma; hepatocellular carcinoma; hepatocellular tumors; predictive markers; prognostic markers; tissue markers

References

  1. Clin Mol Hepatol. 2016 Jun;22(2):199-211 - PubMed
  2. Cancer Res. 1997 Nov 15;57(22):5179-84 - PubMed
  3. Hepatology. 2007 Mar;45(3):725-34 - PubMed
  4. Am J Clin Pathol. 2004 Nov;122(5):721-7 - PubMed
  5. Gut. 2011 Jul;60(7):967-76 - PubMed
  6. Lab Invest. 2008 Jan;88(1):78-88 - PubMed
  7. Mod Pathol. 2016 Mar;29(3):283-92 - PubMed
  8. J Hepatol. 2009 Apr;50(4):746-54 - PubMed
  9. Hum Pathol. 2016 Apr;50:24-33 - PubMed
  10. Am J Surg Pathol. 2010 Aug;34(8):1147-54 - PubMed
  11. Hepatology. 2007 Sep;46(3):740-8 - PubMed
  12. Hepatology. 2016 Dec;64(6):2047-2061 - PubMed
  13. Oncotarget. 2016 Nov 8;7(45):72622-72633 - PubMed
  14. Hum Pathol. 2008 Feb;39(2):209-12 - PubMed
  15. Hum Pathol. 2014 Mar;45(3):658-60 - PubMed
  16. Histopathology. 2015 Mar;66(4):598-602 - PubMed
  17. Hepatology. 2003 Jan;37(1):198-207 - PubMed
  18. Liver Int. 2015 Nov;35(11):2466-73 - PubMed
  19. J Hepatol. 2016 Aug;65(2):386-98 - PubMed
  20. Gastroenterology. 2003 Jul;125(1):89-97 - PubMed
  21. Hepatology. 2008 Aug;48(2):519-30 - PubMed
  22. Hum Pathol. 2016 Apr;50:135-9 - PubMed
  23. Gastroenterology. 2017 Mar;152(4):880-894.e6 - PubMed
  24. Best Pract Res Clin Gastroenterol. 2013 Apr;27(2):269-84 - PubMed
  25. J Hepatol. 2012 Apr;56(4):908-43 - PubMed
  26. Hum Pathol. 2013 Apr;44(4):542-50 - PubMed
  27. Hepatology. 2006 Mar;43(3):515-24 - PubMed
  28. Semin Liver Dis. 2011 Feb;31(1):91-103 - PubMed
  29. Diagn Pathol. 2012 Oct 30;7:149 - PubMed

Publication Types