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Bodranghien F, Oulad Ben Taib N, Van Maldergem L, et al. A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3. Front Neurol. 2017;8:71doi: 10.3389/fneur.2017.00071.
Bodranghien, F., Oulad Ben Taib, N., Van Maldergem, L., & Manto, M. (2017). A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3. Frontiers in neurology, 871. https://doi.org/10.3389/fneur.2017.00071
Bodranghien, Florian, et al. "A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3." Frontiers in neurology vol. 8 (2017): 71. doi: https://doi.org/10.3389/fneur.2017.00071
Bodranghien F, Oulad Ben Taib N, Van Maldergem L, Manto M. A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3. Front Neurol. 2017 Mar 03;8:71. doi: 10.3389/fneur.2017.00071. eCollection 2017. PMID: 28316589; PMCID: PMC5334604.
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Front Neurol. 2017 Mar 03;8:71. doi: 10.3389/fneur.2017.00071. eCollection 2017.

A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3.

Frontiers in neurology

Florian Bodranghien, Nordeyn Oulad Ben Taib, Lionel Van Maldergem, Mario Manto

Affiliations

  1. Unité d'Etude du Mouvement-GRIM, FNRS, ULB-Erasme , Bruxelles , Belgium.
  2. Service de Neurochirurgie, ULB-Erasme, Bruxelles, Belgium; Service de Neurochirurgie, CHU-StPierre, Bruxelles, Belgium.
  3. Centre de génétique humaine, Université de Franche-Comté, Besançon, France; Metabolic Unit, Université de Liège, Liège, Belgium.
  4. Unité d'Etude du Mouvement-GRIM, FNRS, ULB-Erasme, Bruxelles, Belgium; Service des Neurosciences, UMons, Mons, Belgium.

PMID: 28316589 PMCID: PMC5334604 DOI: 10.3389/fneur.2017.00071

Abstract

BACKGROUND AND OBJECTIVES: Cerebellar ataxias are disabling disorders that impact the quality of life of patients. In many cases, an effective treatment is missing. Despite the increasing knowledge on the pathogenesis of cerebellar disorders including genetic aspects, there is currently a gap in the therapeutical management of cerebellar deficits. Cerebellar ataxia associated with ANO10 mutation (ARCA3) presents a disabling cerebellar syndrome. The aim of this study is to report a patient with a marked postural tremor responding to transcranial cerebello-cerebral direct current stimulation (tCCDCS).

METHODS: We applied tCCDCS using anodal stimulation over the cerebellum with a return electrode on the contralateral motor cortex. We performed a clinical rating, accelerometry studies, and recordings of voluntary movements at baseline, after sham, and after active tCCDCS.

RESULTS: A dramatic response of postural tremor was observed after tCCDCS, with a major drop of the power spectral density to 26.12% of basal values.

DISCUSSION: The postural tremor of cerebellar ataxia associated with ANO10 mutation was highly responsive to tCCDCS in our patient. This case illustrates that tCCDCS is a novel therapeutic option in the treatment of cerebellar deficits and might represent a promising tool to reduce tremor in ARCA3.

Keywords: ANO10; Purkinje neurons; cerebellar ataxia; transcranial direct current stimulation; tremor

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