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Hosseinimehr SJ, Fathi M, Ghasemi A, et al. Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes. Res Pharm Sci. 2017;12(1):82-87doi: 10.4103/1735-5362.199051.
Hosseinimehr, S. J., Fathi, M., Ghasemi, A., Shiadeh, S. N., & Pourfallah, T. A. (2017). Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes. Research in pharmaceutical sciences, 12(1), 82-87. https://doi.org/10.4103/1735-5362.199051
Hosseinimehr, Seyed Jalal, et al. "Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes." Research in pharmaceutical sciences vol. 12,1 (2017): 82-87. doi: https://doi.org/10.4103/1735-5362.199051
Hosseinimehr SJ, Fathi M, Ghasemi A, Shiadeh SN, Pourfallah TA. Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes. Res Pharm Sci. 2017 Feb;12(1):82-87. doi: 10.4103/1735-5362.199051. PMID: 28255318; PMCID: PMC5333484.
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Res Pharm Sci. 2017 Feb;12(1):82-87. doi: 10.4103/1735-5362.199051.

Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes.

Research in pharmaceutical sciences

Seyed Jalal Hosseinimehr, Mahdieh Fathi, Arash Ghasemi, Seyedeh Nesa Rezaeian Shiadeh, Tayyeb Allahverdi Pourfallah

Affiliations

  1. Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, I.R. Iran.
  2. Department of Radiology and Radiation Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran.
  3. Department of Biochemistry and Biophysics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran.

PMID: 28255318 PMCID: PMC5333484 DOI: 10.4103/1735-5362.199051

Abstract

Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells. The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. Peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μM of CLX for two hours. At each dose point, the whole blood was exposed

Keywords: Celecoxib; Genotoxicity; Ionizing radiation; Lymphocyte

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