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Hackett G, Jones PW, Strange RC, et al. Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes. World J Diabetes. 2017;8(3):104-111doi: 10.4239/wjd.v8.i3.104.
Hackett, G., Jones, P. W., Strange, R. C., & Ramachandran, S. (2017). Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes. World journal of diabetes, 8(3), 104-111. https://doi.org/10.4239/wjd.v8.i3.104
Hackett, Geoffrey, et al. "Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes." World journal of diabetes vol. 8,3 (2017): 104-111. doi: https://doi.org/10.4239/wjd.v8.i3.104
Hackett G, Jones PW, Strange RC, Ramachandran S. Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes. World J Diabetes. 2017 Mar 15;8(3):104-111. doi: 10.4239/wjd.v8.i3.104. PMID: 28344753; PMCID: PMC5348622.
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World J Diabetes. 2017 Mar 15;8(3):104-111. doi: 10.4239/wjd.v8.i3.104.

Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes.

World journal of diabetes

Geoffrey Hackett, Peter W Jones, Richard C Strange, Sudarshan Ramachandran

Affiliations

  1. Geoffrey Hackett, Department of Urology, University of Bed-fordshire, Bedfordshire, Luton LU1 3JU, United Kingdom.

PMID: 28344753 PMCID: PMC5348622 DOI: 10.4239/wjd.v8.i3.104

Abstract

AIM: To determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic men.

METHODS: We studied 857 diabetic men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total T > 12 nmol/L and free T > 0.25 nmol/L), Low T/untreated and Low T/treated; (2) PDE5I/untreated and PDE5I/treated; and (3) statin/untreated and statin/treated groups. The relationship between age and mortality, alone and with T/TRT, statin and PDE5I treatment was studied using logistic regression. Mortality probability and 95%CI were calculated from the above models for each individual.

RESULTS: Age was associated with mortality (logistic regression, OR = 1.10, 95%CI: 1.08-1.13,

CONCLUSION: We show that statins, PDE5I and TRT reduce mortality in diabetes. PDE5I, alone and with the other treatments significantly alter age related mortality in diabetic men.

Keywords: Gompertz-Makeham equation; Male hypogonadism; Mortality; Phosphodiesterase 5 inhibitors; Statins; Testosterone replacement therapy; Type 2 diabetes

Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.

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