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Peng B, Shi R, Jiang W, et al. Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell Biosci. 2017;7:15doi: 10.1186/s13578-017-0142-x.
Peng, B., Shi, R., Jiang, W., Ding, Y. H., Dong, M. Q., Zhu, W. G., & Xu, X. (2017). Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell & bioscience, 715. https://doi.org/10.1186/s13578-017-0142-x
Peng, Bin, et al. "Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis." Cell & bioscience vol. 7 (2017): 15. doi: https://doi.org/10.1186/s13578-017-0142-x
Peng B, Shi R, Jiang W, Ding YH, Dong MQ, Zhu WG, Xu X. Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis. Cell Biosci. 2017 Mar 23;7:15. doi: 10.1186/s13578-017-0142-x. eCollection 2017. PMID: 28344766; PMCID: PMC5364692.
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Cell Biosci. 2017 Mar 23;7:15. doi: 10.1186/s13578-017-0142-x. eCollection 2017.

Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis.

Cell & bioscience

Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu, Xingzhi Xu

Affiliations

  1. Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, 100048 China.
  2. Guangdong Key Laboratory of Genome Stability & Disease Prevention, Shenzhen University School of Medicine, Shenzhen, 518060 Guangdong China.
  3. National Institute of Biological Sciences, Beijing, 102206 China.

PMID: 28344766 PMCID: PMC5364692 DOI: 10.1186/s13578-017-0142-x

Abstract

BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However, the molecular mechanism of LSD1 detachment is unknown.

RESULTS: In this report, we found that polo-like kinase 1 (PLK1) directly interacted with LSD1 and phosphorylated LSD1 at Ser-126 . Nocodazole-induced metaphase arrest promoted release of LSD1 from chromatin, and the phosphorylation-defective mutant LSD1 (S126A) failed to dissociate from chromatin upon nocodazole treatment.

CONCLUSIONS: Taken together, our findings demonstrate that phosphorylation of LSD1 at Ser-126 by PLK1 promotes its release from chromatin during mitosis.

Keywords: Chromatin release; Lysine-specific demethylase LSD1; Mitosis; PLK1; Phosphorylation

References

  1. J Cell Sci. 2009 Aug 15;122(Pt 16):2957-68 - PubMed
  2. Mol Cell Biol. 2002 Jun;22(12):4419-32 - PubMed
  3. Nat Cell Biol. 2005 Apr;7(4):420-8 - PubMed
  4. Nucleic Acids Res. 2015 Jul 13;43(12 ):5936-47 - PubMed
  5. Nat Rev Mol Cell Biol. 2014 Nov;15(11):703-8 - PubMed
  6. Nature. 2005 Sep 15;437(7057):436-9 - PubMed
  7. J Biol Chem. 2006 Mar 31;281(13):8888-97 - PubMed
  8. Nat Genet. 2010 Aug;42(8):715-21 - PubMed
  9. J Biol Chem. 2003 Mar 7;278(10):8795-803 - PubMed
  10. Cold Spring Harb Perspect Biol. 2016 Apr 01;8(4):a019521 - PubMed
  11. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):97-109 - PubMed
  12. Proc Natl Acad Sci U S A. 1964 May;51:786-94 - PubMed
  13. Cell. 2004 Dec 29;119(7):941-53 - PubMed
  14. Sci Rep. 2015 Feb 10;5:8360 - PubMed
  15. J Proteome Res. 2002 Jan-Feb;1(1):21-6 - PubMed
  16. Biochim Biophys Acta. 2014 Aug;1839(8):627-43 - PubMed
  17. Oncogene. 2015 Sep 10;34(37):4799-807 - PubMed
  18. Nat Commun. 2015 Apr 09;6:6744 - PubMed
  19. Cancer Sci. 2016 Sep;107(9):1187-92 - PubMed
  20. Science. 1967 Sep 15;157(3794):1324-5 - PubMed
  21. Nat Methods. 2012 Sep;9(9):904-6 - PubMed
  22. Eur J Cell Biol. 2010 Jul;89(7):557-63 - PubMed
  23. Mol Cell Biol. 2012 Dec;32(23):4861-76 - PubMed
  24. Biochem Biophys Res Commun. 2014 May 16;447(4):702-6 - PubMed
  25. Nature. 2006 Jul 20;442(7100):307-11 - PubMed
  26. Nat Cell Biol. 2007 Mar;9(3):347-53 - PubMed

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