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Iglesias-Garcia J, Lindkvist B, Lariño-Noia J, et al. Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both?. United European Gastroenterol J. 2016;5(2):236-246doi: 10.1177/2050640616640635.
Iglesias-Garcia, J., Lindkvist, B., Lariño-Noia, J., Abdulkader-Nallib, I., & Dominguez-Muñoz, J. E. (2017). Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both?. United European gastroenterology journal, 5(2), 236-246. https://doi.org/10.1177/2050640616640635
Iglesias-Garcia, Julio, et al. "Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both?." United European gastroenterology journal vol. 5,2 (2017): 236-246. doi: https://doi.org/10.1177/2050640616640635
Iglesias-Garcia J, Lindkvist B, Lariño-Noia J, Abdulkader-Nallib I, Dominguez-Muñoz JE. Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both?. United European Gastroenterol J. 2017 Mar;5(2):236-246. doi: 10.1177/2050640616640635. Epub 2016 Jun 23. PMID: 28344791; PMCID: PMC5349356.
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United European Gastroenterol J. 2017 Mar;5(2):236-246. doi: 10.1177/2050640616640635. Epub 2016 Jun 23.

Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both?.

United European gastroenterology journal

Julio Iglesias-Garcia, Björn Lindkvist, Jose Lariño-Noia, Ihab Abdulkader-Nallib, J Enrique Dominguez-Muñoz

Affiliations

  1. Department of Gastroenterology and Instituto de Investigación Sanitaria de Santiago (IDIS), University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
  2. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  3. Department of Pathology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

PMID: 28344791 PMCID: PMC5349356 DOI: 10.1177/2050640616640635

Abstract

BACKGROUND: Contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) and quantitative-elastography endoscopic ultrasound (QE-EUS) are considered useful tools for the evaluation of solid pancreatic tumors (SPT). The aim of our study was to evaluate the diagnostic accuracy of CEH-EUS, QE-EUS, and the combination of both for the differential diagnosis of SPT.

METHODS: Sixty-two consecutive patients (mean age 64.3 years, range 32-89 years, 44 male) who underwent EUS for the evaluation of SPT were prospectively included. EUS was performed with a linear Pentax-EUS and a Hitachi-Preirus processor. The mass (area A) and a reference area B were selected during QE-EUS, and results expressed as B/A (strain ratio). A strain histogram of the mass was also evaluated. Microvascularization of the tumor was evaluated over 2 min during CEH-EUS after intravenous injection of 4.8 mL SonoVue. Final diagnosis was based on histopathology of surgical specimens or EUS-guided tissue acquisition and clinical follow-up in non-operated cases. Diagnostic accuracy of CEH-EUS, QE-EUS, and their combination was calculated.

RESULTS: Median size of the masses was 32 mm (range 12-111). Final diagnosis was pancreatic adenocarcinoma (

CONCLUSION: The combination of QE-EUS and CEH-EUS is a useful tool for the differential diagnosis of SPT, giving complementary information. However, this combination does not significantly increase the diagnostic accuracy of either of the techniques performed alone.

Keywords: Solid pancreatic lesion; endoscopic ultrasound; stiffness; tissue acquisition; vascularization

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