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ACS Biomater Sci Eng. 2017 Mar 13;3(3):349-359. doi: 10.1021/acsbiomaterials.6b00622. Epub 2017 Jan 22.

Reduction of Thrombosis and Bacterial Infection via Controlled Nitric Oxide (NO) Release from .

ACS biomaterials science & engineering

Yaqi Wo, Elizabeth J Brisbois, Jianfeng Wu, Zi Li, Terry C Major, Azmath Mohammed, Xianglong Wang, Alessandro Colletta, Joseph L Bull, Adam J Matzger, Chuanwu Xi, Robert H Bartlett, Mark E Meyerhoff

Affiliations

  1. Department of Chemistry, Department of Surgery, University of Michigan Medical Center, Department of Environmental Health Sciences, and Department of Biomedical Engineering, University of Michigan , Ann Arbor, Michigan 48109, United States.

PMID: 28317023 PMCID: PMC5351555 DOI: 10.1021/acsbiomaterials.6b00622

Abstract

Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led to great interest in the development of biomaterials that can deliver NO for specific biomedical applications. Herein, we report a simple solvent impregnation technique to incorporate a nontoxic NO donor,

Keywords: S-nitroso-N-acetylpenicillamine (SNAP); antimicrobial catheters; bactericidal; nitric oxide; solvent impregnation; thromboresistance

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