Display options
Cite
Olatosi JO, Ehiozie-Osifo A. EFFICACY OF INTRAVENOUS ESMOLOL VERSUS LIDOCAINE FOR ATTENUATION OF THE PRESSOR RESPONSE IN NIGERIANS. J West Afr Coll Surg. 2016;6(1):47-69
Olatosi, J. O., & Ehiozie-Osifo, A. (2016). EFFICACY OF INTRAVENOUS ESMOLOL VERSUS LIDOCAINE FOR ATTENUATION OF THE PRESSOR RESPONSE IN NIGERIANS. Journal of the West African College of Surgeons, 6(1), 47-69.
Olatosi, J O, and Ehiozie-Osifo, A. "EFFICACY OF INTRAVENOUS ESMOLOL VERSUS LIDOCAINE FOR ATTENUATION OF THE PRESSOR RESPONSE IN NIGERIANS." Journal of the West African College of Surgeons vol. 6,1 (2016): 47-69.
Olatosi JO, Ehiozie-Osifo A. EFFICACY OF INTRAVENOUS ESMOLOL VERSUS LIDOCAINE FOR ATTENUATION OF THE PRESSOR RESPONSE IN NIGERIANS. J West Afr Coll Surg. 2016 Jan-Mar;6(1):47-69. PMID: 28344937; PMCID: PMC5342620.
Copy Download .nbib Format: NLM
Share it on

J West Afr Coll Surg. 2016 Jan-Mar;6(1):47-69.

EFFICACY OF INTRAVENOUS ESMOLOL VERSUS LIDOCAINE FOR ATTENUATION OF THE PRESSOR RESPONSE IN NIGERIANS.

Journal of the West African College of Surgeons

J O Olatosi, A Ehiozie-Osifo

Affiliations

  1. Department of Anaesthesia, Lagos University Teaching Hospital, Lagos, Nigeria.

PMID: 28344937 PMCID: PMC5342620

Abstract

BACKGROUND: Laryngoscopy and tracheal intubation are an integral component of airway management and general anaesthesia. Direct stimulation of the pharynx and larynx by the laryngoscope blade and the insertion of an endotracheal tube elicit a sympathetic nervous system response with a reflex consisting of a transient increase in blood pressure, heart rate, and the occurrence of cardiac dysrhythmias referred to as the 'pressor' response. This may be of major clinical significance in patients with pre-existing systemic hypertension, hypertensive heart disease, coronary artery disease, eclampsia, aneurysmal vascular disease and head injury in whom such a change may culminate in perioperative myocardial ischaemia or infarction, cardiac failure, dysrhythmias, cerebrovascular accidents or secondary brain injury.

AIM: To evaluate and compare the effects of intravenous lidocaine and esmolol on the pressor response as well as determine the occurrence of complications with the use of either agent in a Nigerian population.

METHODOLOGY: Ninety adult ASA I and II patients undergoing elective non-cardiac surgery under general anaesthesia were randomly allocated to one of 3 groups; group E: 2mg.kg

RESULTS: Mean heart rate increased by 19.1%, 25.7%, and 41.4%, SBP increased 13.3%, 21.6% and 26.9%, MAP by 12.2%, 19.1% and 30.2%, RPP by 28.1%, 45.8% and 78.7% in groups E, L and C respectively post intubation. There were no complications attributable to the use of either agent.

CONCLUSION: Intravenous esmolol 2mg.kg

Keywords: Blood pressure; Esmolol; Heart rate; Intubation; Laryngoscopy; Lidocaine

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

  1. Br J Anaesth. 1983 Sep;55(9):855-60 - PubMed
  2. Can J Anaesth. 1991 Oct;38(7):849-58 - PubMed
  3. Anesthesiology. 1977 Dec;47(6):524-5 - PubMed
  4. Br J Anaesth. 2006 Jun;96(6):769-73 - PubMed
  5. Anesth Analg. 1991 Apr;72(4):482-6 - PubMed
  6. Eur J Anaesthesiol. 2008 Jun;25(6):517-9 - PubMed
  7. J Clin Anesth. 1992 Sep-Oct;4(5):367-71 - PubMed
  8. Clin Pharmacol Ther. 1987 Jan;41(1):112-7 - PubMed
  9. Can Anaesth Soc J. 1977 Jan;24(1):12-9 - PubMed
  10. Anesthesiology. 1983 Dec;59(6):499-505 - PubMed
  11. Anesthesiology. 1951 Sep;12(5):556-66 - PubMed
  12. Lancet Glob Health. 2015 Sep;3(9):e514-5 - PubMed
  13. Anesth Analg. 1989 Jun;68(6):772-6 - PubMed
  14. Anesthesiology. 1981 Nov;55(5):578-81 - PubMed
  15. J Emerg Med. 1994 Jul-Aug;12(4):499-506 - PubMed
  16. Br J Anaesth. 1971 Jun;43(6):531-47 - PubMed
  17. Acta Anaesthesiol Sin. 1996 Jun;34(2):61-7 - PubMed
  18. Can J Anaesth. 2001 Sep;48(8):732-6 - PubMed

Publication Types