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Chem Commun (Camb). 2017 Apr 06;53(29):4096-4099. doi: 10.1039/c7cc01434a.

Nontoxic organic solvents identified using an a priori approach with Hansen solubility parameters.

Chemical communications (Cambridge, England)

Daisuke Nakamura, Minoru Hirano, Riichiro Ohta

Affiliations

  1. Toyota Central R&D Labs., Inc., Nagakute, Aichi 480-1192, Japan. [email protected].

PMID: 28345101 DOI: 10.1039/c7cc01434a

Abstract

Nontoxicities of organic solvents were predicted using Hansen solubility parameters and various truly nontoxic solvents were identified according to the prediction. The nontoxicity of solvents originates from their exhibition of poor solubility or low diffusivity toward cell constituents and good stability against hydrolytic degradation.

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