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An S, Cha HJ, Ko JM, et al. Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers. Ann Dermatol. 2017;29(1):6-12doi: 10.5021/ad.2017.29.1.6.
An, S., Cha, H. J., Ko, J. M., Han, H., Kim, S. Y., Kim, K. S., Lee, S. J., An, I. S., Kim, S., Youn, H. J., Ahn, K. J., & Kim, S. Y. (2017). Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers. Annals of dermatology, 29(1), 6-12. https://doi.org/10.5021/ad.2017.29.1.6
An, Sungkwan, et al. "Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers." Annals of dermatology vol. 29,1 (2017): 6-12. doi: https://doi.org/10.5021/ad.2017.29.1.6
An S, Cha HJ, Ko JM, Han H, Kim SY, Kim KS, Lee SJ, An IS, Kim S, Youn HJ, Ahn KJ, Kim SY. Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers. Ann Dermatol. 2017 Feb;29(1):6-12. doi: 10.5021/ad.2017.29.1.6. Epub 2017 Feb 02. PMID: 28223740; PMCID: PMC5318528.
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Ann Dermatol. 2017 Feb;29(1):6-12. doi: 10.5021/ad.2017.29.1.6. Epub 2017 Feb 02.

Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers.

Annals of dermatology

Sungkwan An, Hwa Jun Cha, Jung-Min Ko, Hyunjoo Han, Su Young Kim, Kyung-Suk Kim, Song Jeong Lee, In-Sook An, Sangwon Kim, Hae Jeong Youn, Kyu Joong Ahn, Soo-Yeon Kim

Affiliations

  1. Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul, Korea.
  2. KISCS Incorporated, Cheongju, Korea.
  3. Orangewood Christian School, Maitland, FL, USA.
  4. Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

PMID: 28223740 PMCID: PMC5318528 DOI: 10.5021/ad.2017.29.1.6

Abstract

BACKGROUND: Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier.

OBJECTIVE: We examined whether kinetin induces skin barrier functions

METHODS: To evaluate the efficacy of kinetin at the cellular level, expression of keratinocyte differentiation markers was assessed. Moreover, we examined the clinical efficacy of kinetin by evaluating skin moisture, transepidermal water loss (TEWL), and skin surface roughness in patients who used kinetin-containing cream. We performed quantitative real-time polymerase chain reaction to measure the expression of keratinocyte differentiation markers in HaCaT cells following treatment. A clinical trial was performed to assess skin moisture, TEWL, and evenness of skin texture in subjects who used kinetin-containing cream for 4 weeks.

RESULTS: Kinetin increased involucrin, and keratin 1 mRNA in HaCaT cells. Moreover, use of a kinetin-containing cream improved skin moisture and TEWL while decreasing roughness of skin texture.

CONCLUSION: Kinetin induced the expression of keratinocyte differentiation markers, suggesting that it may affect differentiation to improve skin moisture content, TEWL, and other signs of skin aging. Therefore, kinetin is a potential new component for use in cosmetics as an anti-aging agent that improves the barrier function of skin.

Keywords: Cell culture techniques; Differentiation; Keratinocytes; Kinetin; Skin barrier

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