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Hospital MA, Green AS, Maciel TT, et al. FLT3 inhibitors: clinical potential in acute myeloid leukemia. Onco Targets Ther. 2017;10:607-615doi: 10.2147/OTT.S103790.
Hospital, M. A., Green, A. S., Maciel, T. T., Moura, I. C., Leung, A. Y., Bouscary, D., & Tamburini, J. (2017). FLT3 inhibitors: clinical potential in acute myeloid leukemia. OncoTargets and therapy, 10607-615. https://doi.org/10.2147/OTT.S103790
Hospital, Marie-Anne, et al. "FLT3 inhibitors: clinical potential in acute myeloid leukemia." OncoTargets and therapy vol. 10 (2017): 607-615. doi: https://doi.org/10.2147/OTT.S103790
Hospital MA, Green AS, Maciel TT, Moura IC, Leung AY, Bouscary D, Tamburini J. FLT3 inhibitors: clinical potential in acute myeloid leukemia. Onco Targets Ther. 2017 Feb 03;10:607-615. doi: 10.2147/OTT.S103790. eCollection 2017. PMID: 28223820; PMCID: PMC5304990.
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Onco Targets Ther. 2017 Feb 03;10:607-615. doi: 10.2147/OTT.S103790. eCollection 2017.

FLT3 inhibitors: clinical potential in acute myeloid leukemia.

OncoTargets and therapy

Marie-Anne Hospital, Alexa S Green, Thiago T Maciel, Ivan C Moura, Anskar Y Leung, Didier Bouscary, Jerome Tamburini

Affiliations

  1. Département Développement, Reproduction, Cancer, Institut Cochin, Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016; Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC).
  2. INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications; Paris Descartes - Sorbonne Paris Cité University; CNRS ERL 8254, Imagine Institute; Laboratory of Excellence GR-Ex, Paris, France.
  3. Department of Medicine, Division of Hematology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.

PMID: 28223820 PMCID: PMC5304990 DOI: 10.2147/OTT.S103790

Abstract

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that is cured in as few as 15%-40% of cases. Tremendous improvements in AML prognostication arose from a comprehensive analysis of leukemia cell genomes. Among normal karyotype AML cases, mutations in the

Keywords: AML; FLT3; FLT3-ITD; resistance mechanisms; target therapy; tyrosine kinase

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

  1. Cell Stem Cell. 2011 Jul 8;9(1):64-73 - PubMed
  2. Blood. 2011 Jun 30;117(26):6987-90 - PubMed
  3. Leukemia. 2015 Dec;29(12):2382-9 - PubMed
  4. Blood. 2014 Apr 17;123(16):2530-9 - PubMed
  5. Leukemia. 2013 Feb;27(2):260-8 - PubMed
  6. Sci Adv. 2015 Sep 18;1(8):e1500221 - PubMed
  7. Cell. 1991 Jun 28;65(7):1143-52 - PubMed
  8. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5319-24 - PubMed
  9. Leukemia. 2009 Apr;23(4):729-38 - PubMed
  10. Blood. 2004 Jan 1;103(1):267-74 - PubMed
  11. Blood. 2007 Jul 1;110(1):370-4 - PubMed
  12. Blood. 2013 Apr 4;121(14):2734-8 - PubMed
  13. Cancer Res. 2011 Jul 1;71(13):4696-706 - PubMed
  14. Oncotarget. 2016 Jun 28;7(26):40387-40397 - PubMed
  15. BMC Cancer. 2012 Jul 23;12:304 - PubMed
  16. Nature. 2001 May 17;411(6835):355-65 - PubMed
  17. Blood. 2012 May 10;119(19):4499-511 - PubMed
  18. J Biol Chem. 2015 Apr 10;290(15):9348-61 - PubMed
  19. Blood. 2009 Jun 25;113(26):6567-71 - PubMed
  20. Blood. 2005 Mar 1;105(5):2107-14 - PubMed
  21. Blood. 2013 Nov 21;122(22):3547-8 - PubMed
  22. Leukemia. 2016 Feb;30(2):473-83 - PubMed
  23. Genes Chromosomes Cancer. 2012 Jul;51(7):689-95 - PubMed
  24. Nat Commun. 2016 Aug 18;7:12475 - PubMed
  25. Leukemia. 2012 Oct;26(10 ):2233-44 - PubMed
  26. Oncotarget. 2015 Sep 8;6(26):22812-21 - PubMed
  27. Haematologica. 2010 Jun;95(6):1004-15 - PubMed
  28. Blood. 1992 Nov 15;80(10):2584-93 - PubMed
  29. Neoplasia. 2014 May;16(5):403-12 - PubMed
  30. Cell. 2012 Jul 20;150(2):264-78 - PubMed
  31. Blood. 2002 Jun 15;99(12):4326-35 - PubMed
  32. Cell Rep. 2014 Nov 20;9(4):1333-48 - PubMed
  33. Blood. 2014 Nov 27;124(23):3441-9 - PubMed
  34. Blood. 2012 Aug 23;120(8):1691-702 - PubMed
  35. Leukemia. 1996 Dec;10(12):1911-8 - PubMed
  36. Blood. 2011 Jul 21;118(3):693-702 - PubMed
  37. Br J Haematol. 2016 Nov;175(3):496-504 - PubMed
  38. Blood. 2009 Aug 20;114(8):1618-27 - PubMed
  39. Cancer Cell. 2014 Feb 10;25(2):226-42 - PubMed
  40. Blood. 2001 Apr 15;97(8):2434-9 - PubMed
  41. J Clin Oncol. 2013 Oct 10;31(29):3681-7 - PubMed
  42. Blood. 2009 Apr 9;113(15):3568-76 - PubMed
  43. Nature. 2012 Jan 11;481(7382):506-10 - PubMed
  44. Blood. 2010 Feb 18;115(7):1425-32 - PubMed
  45. Immunity. 1995 Jul;3(1):147-61 - PubMed
  46. Sci Transl Med. 2016 Oct 5;8(359):359ra129 - PubMed
  47. J Clin Oncol. 2012 Oct 10;30(29):3604-10 - PubMed
  48. Eur J Haematol. 2016 Jun;96(6):629-36 - PubMed
  49. Pediatr Blood Cancer. 2015 Jun;62(6):1048-54 - PubMed
  50. Leukemia. 2012 Jun;26(6):1228-37 - PubMed
  51. Leukemia. 1998 Sep;12(9):1333-7 - PubMed
  52. PLoS One. 2014 Mar 07;9(3):e89560 - PubMed
  53. Blood. 2005 Feb 15;105(4):1759-67 - PubMed
  54. Lancet Oncol. 2015 Dec;16(16):1691-9 - PubMed
  55. J Clin Invest. 2012 Aug;122(8):2955-66 - PubMed
  56. EMBO Rep. 2015 Mar;16(3):280-96 - PubMed
  57. Blood. 2015 Nov 26;126(22):2491-501 - PubMed
  58. Blood. 2013 Apr 18;121(16):3165-71 - PubMed
  59. Clin Cancer Res. 2015 Mar 15;21(6):1360-72 - PubMed
  60. Expert Opin Ther Targets. 2015 Jan;19(1):37-54 - PubMed
  61. Clin Lymphoma Myeloma Leuk. 2015 May;15(5):298-302 - PubMed
  62. N Engl J Med. 2012 Mar 22;366(12):1079-89 - PubMed
  63. Leukemia. 2008 Jan;22(1):78-86 - PubMed
  64. Cancer Res. 2006 Apr 1;66(7):3828-35 - PubMed
  65. Blood. 2011 Mar 24;117(12 ):3286-93 - PubMed
  66. Cancer Cell. 2016 Apr 11;29(4):548-62 - PubMed
  67. Chem Biol. 2013 Jun 20;20(6):745-6 - PubMed
  68. Blood. 2012 May 31;119(22):5133-43 - PubMed
  69. Blood. 2004 Mar 1;103(5):1883-90 - PubMed
  70. Biol Blood Marrow Transplant. 2014 Dec;20(12):2042-8 - PubMed
  71. Blood. 2012 Nov 15;120(20):4205-14 - PubMed
  72. N Engl J Med. 2016 Jun 9;374(23 ):2209-21 - PubMed
  73. Cancer. 2014 Jul 15;120(14):2142-9 - PubMed
  74. Cell Stem Cell. 2012 Sep 7;11(3):346-58 - PubMed
  75. Nature. 2014 Feb 20;506(7488):328-33 - PubMed
  76. Clin Cancer Res. 2014 Apr 1;20(7):1834-45 - PubMed
  77. Blood. 2014 Feb 6;123(6):905-13 - PubMed

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