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Albert M, Corsilli D, Williamson DR, et al. Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med. 2017;6(1):74-78doi: 10.5492/wjccm.v6.i1.74.
Albert, M., Corsilli, D., Williamson, D. R., Brosseau, M., Bellemare, P., Delisle, S., Nguyen, A. Q., & Varin, F. (2017). Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World journal of critical care medicine, 6(1), 74-78. https://doi.org/10.5492/wjccm.v6.i1.74
Albert, Martin, et al. "Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome." World journal of critical care medicine vol. 6,1 (2017): 74-78. doi: https://doi.org/10.5492/wjccm.v6.i1.74
Albert M, Corsilli D, Williamson DR, Brosseau M, Bellemare P, Delisle S, Nguyen AQ, Varin F. Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med. 2017 Feb 04;6(1):74-78. doi: 10.5492/wjccm.v6.i1.74. eCollection 2017 Feb 04. PMID: 28224110; PMCID: PMC5295172.
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World J Crit Care Med. 2017 Feb 04;6(1):74-78. doi: 10.5492/wjccm.v6.i1.74. eCollection 2017 Feb 04.

Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome.

World journal of critical care medicine

Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin

Affiliations

  1. Martin Albert, Departments of Intensive Care and Medicine, Hôpital du Sacré-Coeur, de Montréal Research Center, Université de Montréal, Montréal H4J 1C5, Canada.

PMID: 28224110 PMCID: PMC5295172 DOI: 10.5492/wjccm.v6.i1.74

Abstract

AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS).

METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients. Thereafter, inhaled milrinone (1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide (iNO) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen (PaO

RESULTS: The majority of ARDS were of pulmonary cause (

CONCLUSION: When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS.

Keywords: Acute respiratory distress syndrome; Hypoxemia; Inhaled milrinone; Nitric oxide; Prostacyclin; Pulmonary hypertension

Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.

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