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Walker JA, Ewald TJ, Lewallen E, et al. Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints. Bone Joint Res. 2017;6(3):162-171doi: 10.1302/2046-3758.63.BJR-2016-0193.
Walker, J. A., Ewald, T. J., Lewallen, E., Van Wijnen, A., Hanssen, A. D., Morrey, B. F., Morrey, M. E., Abdel, M. P., & Sanchez-Sotelo, J. (2017). Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints. Bone & joint research, 6(3), 162-171. https://doi.org/10.1302/2046-3758.63.BJR-2016-0193
Walker, J A, et al. "Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints." Bone & joint research vol. 6,3 (2017): 162-171. doi: https://doi.org/10.1302/2046-3758.63.BJR-2016-0193
Walker JA, Ewald TJ, Lewallen E, Van Wijnen A, Hanssen AD, Morrey BF, Morrey ME, Abdel MP, Sanchez-Sotelo J. Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints. Bone Joint Res. 2017 Mar;6(3):162-171. doi: 10.1302/2046-3758.63.BJR-2016-0193. PMID: 28347978; PMCID: PMC5376662.
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Bone Joint Res. 2017 Mar;6(3):162-171. doi: 10.1302/2046-3758.63.BJR-2016-0193.

Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints.

Bone & joint research

J A Walker, T J Ewald, E Lewallen, A Van Wijnen, A D Hanssen, B F Morrey, M E Morrey, M P Abdel, J Sanchez-Sotelo

Affiliations

  1. Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
  2. Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA [email protected].

PMID: 28347978 PMCID: PMC5376662 DOI: 10.1302/2046-3758.63.BJR-2016-0193

Abstract

OBJECTIVES: Sustained intra-articular delivery of pharmacological agents is an attractive modality but requires use of a safe carrier that would not induce cartilage damage or fibrosis. Collagen scaffolds are widely available and could be used intra-articularly, but no investigation has looked at the safety of collagen scaffolds within synovial joints. The aim of this study was to determine the safety of collagen scaffold implantation in a validated

MATERIALS AND METHODS: A total of 96 rabbits were randomly and equally assigned to four different groups: arthrotomy alone; arthrotomy and collagen scaffold placement; contracture surgery; and contracture surgery and collagen scaffold placement. Animals were killed in equal numbers at 72 hours, two weeks, eight weeks, and 24 weeks. Joint contracture was measured, and cartilage and synovial samples underwent histological analysis.

RESULTS: Animals that underwent arthrotomy had equivalent joint contractures regardless of scaffold implantation (-13.9°

© 2017 Sanchez-Sotelo et al.

Keywords: Arthrofibrosis; Biocompatibility; Biodegradation; Collagen scaffold; Knee joint

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