Display options
Cite
Bertolai R, Catelani C, Signorini M, et al. Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions. Clin Cases Miner Bone Metab. 2017;13(3):214-220doi: 10.11138/ccmbm/2016.13.3.214.
Bertolai, R., Catelani, C., Signorini, M., Rossi, A., & Giannini, D. (2016). Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 13(3), 214-220. https://doi.org/10.11138/ccmbm/2016.13.3.214
Bertolai, Roberto, et al. "Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions." Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases vol. 13,3 (2016): 214-220. doi: https://doi.org/10.11138/ccmbm/2016.13.3.214
Bertolai R, Catelani C, Signorini M, Rossi A, Giannini D. Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions. Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):214-220. doi: 10.11138/ccmbm/2016.13.3.214. Epub 2017 Feb 10. PMID: 28228785; PMCID: PMC5318175.
Copy Download .nbib Format: NLM
Share it on

Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):214-220. doi: 10.11138/ccmbm/2016.13.3.214. Epub 2017 Feb 10.

Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

Roberto Bertolai, Carlo Catelani, Mattia Signorini, Alessandro Rossi, Domenico Giannini

Affiliations

  1. University of Florence, School of Human Health Sciences, Surgery and Translational Medicine Department (DCMT), Head and Neck Unit, Florence, Italy.

PMID: 28228785 PMCID: PMC5318175 DOI: 10.11138/ccmbm/2016.13.3.214

Abstract

BACKGROUND: Recent studies have highlighted that MSCs are capable of regenerating large bone defects when used in combination with bone substitutes and increasing allo-graft osteointegration. We investigated the hypothesis that autologous MSCs may lead to increased bone regeneration and reduced healing time in post-surgical cavities of large maxillary bone lesions.

METHODS: This study involved 10 patients (TEST GROUP) (6 males and 4 females). All patients had expansive mandibular lesions larger than 3 cm. From the surgical point of view, the 10 patients were treated with MSCs (withdrawal of the iliac crest bone marrow BMMSs) directly into the post-surgical cavity, without the addition of filler.

RESULTS: and radiological data, in the postoperative, were compared to those of patients who did not receive any grafting of MSCs. The 7 patients with mandibular lesions showed a rapid and very good healing with an 85-90% ossification of the major defect at 12 months.

CONCLUSIONS: Through the use of stem cells a greater ossification of the residual cavity (85-90%) was observed at 12 months after surgical enucleation in contenitive defects.

Keywords: MSCs; bone grafts; bone regeneration; maxillary bone cysts; maxillary defects

References

  1. Biomaterials. 1993;14(2):115-21 - PubMed
  2. J Periodontol. 1976 Oct;47(10):596-606 - PubMed
  3. Stem Cells. 2010 Aug;28(8):1446-55 - PubMed
  4. Br J Oral Maxillofac Surg. 1992 Jun;30(3):180-2 - PubMed
  5. J Oral Maxillofac Surg. 1996 Nov;54(11):1282-6 - PubMed
  6. J Oral Maxillofac Surg. 2000 Sep;58(9):942-8; discussion 949 - PubMed
  7. Science. 2005 Jul 8;309(5732):314-7 - PubMed
  8. Cell Tissue Kinet. 1970 Oct;3(4):393-403 - PubMed
  9. J Orthop Res. 2006 May;24(5):877-88 - PubMed
  10. Int J Oral Maxillofac Implants. 2005 Jul-Aug;20(4):511-8 - PubMed
  11. Implant Dent. 2001;10(3):178-81 - PubMed
  12. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Apr;79(4):517-25 - PubMed
  13. Cancer. 1992 Dec 15;70(12):2988-94 - PubMed
  14. Nat Med. 1999 Mar;5(3):309-13 - PubMed
  15. Int J Oral Maxillofac Surg. 1998 Apr;27(2):118-20 - PubMed
  16. Handb Exp Pharmacol. 2006;(174):249-82 - PubMed
  17. J Oral Maxillofac Surg. 1994 Sep;52(9):960-3 - PubMed
  18. Dentomaxillofac Radiol. 1998 May;27(3):166-71 - PubMed
  19. Leukemia. 2006 May;20(5):857-69 - PubMed
  20. Clin Cases Miner Bone Metab. 2015 May-Aug;12(2):183-7 - PubMed
  21. J Craniomaxillofac Surg. 2012 Sep;40(6):485-93 - PubMed
  22. Eur J Neurosci. 2001 Dec;14(11):1771-6 - PubMed
  23. Cytotherapy. 2006;8(4):315-7 - PubMed
  24. J Oral Sci. 2004 Dec;46(4):253-7 - PubMed
  25. J Clin Periodontol. 2006 Nov;33(11):837-45 - PubMed
  26. Cytotherapy. 2012 May;14(5):516-21 - PubMed
  27. Head Neck. 1989 Nov-Dec;11(6):516-23 - PubMed
  28. J Clin Periodontol. 2005 Sep;32(9):966-72 - PubMed
  29. Biomaterials. 2003 Aug;24(18):3095-100 - PubMed
  30. N Engl J Med. 2003 Aug 7;349(6):570-82 - PubMed
  31. Pharmacol Ther. 2011 Jan;129(1):21-8 - PubMed
  32. J Oral Pathol Med. 2006 Oct;35(9):525-9 - PubMed
  33. J Craniomaxillofac Surg. 1988 May;16(4):184-95 - PubMed
  34. Blood. 2008 Nov 1;112(9):3543-53 - PubMed
  35. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8639-43 - PubMed
  36. Science. 1999 Apr 2;284(5411):143-7 - PubMed
  37. Int J Oral Maxillofac Surg. 2001 Feb;30(1):14-25 - PubMed
  38. J Clin Invest. 2004 Jun;113(12):1701-10 - PubMed
  39. Minerva Stomatol. 2004 May;53(5):251-61 - PubMed
  40. J Bone Joint Surg Am. 1998 Jul;80(7):985-96 - PubMed
  41. J Cell Sci. 2004 Jun 15;117(Pt 14):2971-81 - PubMed

Publication Types