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Heimbach EJ, Bowden RG, Griggs JO, et al. The Effects of Lowering Uric Acid Levels Using Allopurinol on Components of Metabolic Syndrome. Cardiol Res. 2012;3(2):80-86doi: 10.4021/cr168w.
Heimbach, E. J., Bowden, R. G., Griggs, J. O., Beaujean, A. A., Doyle, E. I., & Doyle, R. D. (2012). The Effects of Lowering Uric Acid Levels Using Allopurinol on Components of Metabolic Syndrome. Cardiology research, 3(2), 80-86. https://doi.org/10.4021/cr168w
Heimbach, Esther J, et al. "The Effects of Lowering Uric Acid Levels Using Allopurinol on Components of Metabolic Syndrome." Cardiology research vol. 3,2 (2012): 80-86. doi: https://doi.org/10.4021/cr168w
Heimbach EJ, Bowden RG, Griggs JO, Beaujean AA, Doyle EI, Doyle RD. The Effects of Lowering Uric Acid Levels Using Allopurinol on Components of Metabolic Syndrome. Cardiol Res. 2012 Apr;3(2):80-86. doi: 10.4021/cr168w. Epub 2012 Mar 20. PMID: 28348676; PMCID: PMC5358145.
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Cardiol Res. 2012 Apr;3(2):80-86. doi: 10.4021/cr168w. Epub 2012 Mar 20.

The Effects of Lowering Uric Acid Levels Using Allopurinol on Components of Metabolic Syndrome.

Cardiology research

Esther J Heimbach, Rodney G Bowden, Jackson O Griggs, A Alexander Beaujean, Eva I Doyle, Robert D Doyle

Affiliations

  1. Baylor University, Waco, Texas, USA.
  2. Family Health Center, Waco, Texas, USA.

PMID: 28348676 PMCID: PMC5358145 DOI: 10.4021/cr168w

Abstract

BACKGROUND: Researchers have reported an independent direct relationship between lipid levels and hyperuricemia with MetS. The purpose of this study was to determine the relationship between serum uric acid levels and lipids among patients on allopurinol.

METHODS: A retrospective secondary data analysis was conducted on 66 adult patients from a family health clinic in Central Texas. Medical records used were recorded during a nine year period (2002 - 2010) ascertaining the relationship between uric acid and lipids.

RESULTS: Spearman correlations revealed a weak correlation between uric acid and total cholesterol, a weak correlation between uric acid and triglycerides and LDL-C. A weak inverse correlation was discovered between uric acid and HDL-C. A moderate correlation was discovered when all lipid variables combined were compared to uric acid.

CONCLUSIONS: We discovered LDL-C and triglycerides to be significant predictors of uric acid with weak correlations. Additionally, weak correlations existed between uric acid and total cholesterol and HDL-C with an inverse relationship discovered with HDL-C. These findings support the literature suggesting that uric acid is more likely to be associated with total cholesterol and triglycerides. In addition, new discoveries serve as an indication that LDL-C may also be associated with uric acids levels. The mechanism by which uric acid may regulate lipids is elusive but suggestions have included suppression of lipid peroxidase and decreases in critical lipase activity.

Keywords: Cholesterol; Gout; HDL; Hyperuricemia; LDL

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