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Shin MS, Kim TW, Lee JM, et al. Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. J Exerc Rehabil. 2017;13(1):30-35doi: 10.12965/jer.1734906.453.
Shin, M. S., Kim, T. W., Lee, J. M., Ji, E. S., & Lim, B. V. (2017). Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. Journal of exercise rehabilitation, 13(1), 30-35. https://doi.org/10.12965/jer.1734906.453
Shin, Mal-Soon, et al. "Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats." Journal of exercise rehabilitation vol. 13,1 (2017): 30-35. doi: https://doi.org/10.12965/jer.1734906.453
Shin MS, Kim TW, Lee JM, Ji ES, Lim BV. Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. J Exerc Rehabil. 2017 Feb 28;13(1):30-35. doi: 10.12965/jer.1734906.453. eCollection 2017 Feb. PMID: 28349030; PMCID: PMC5331996.
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J Exerc Rehabil. 2017 Feb 28;13(1):30-35. doi: 10.12965/jer.1734906.453. eCollection 2017 Feb.

Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats.

Journal of exercise rehabilitation

Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Lim

Affiliations

  1. School of Global Sport Studies, Korea University, Sejong, Korea.
  2. Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
  3. Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea.

PMID: 28349030 PMCID: PMC5331996 DOI: 10.12965/jer.1734906.453

Abstract

Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 consecutive days. Rota-rod test for motor balance and coordination and immunohistochemistry for tyrosine hydroxylase and α-synuclein in the nigrostriatum were performed. In the present study, motor balance and coordination was disturbed by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise alleviated motor dysfunction in the rotenone-induced Parkinson rats. Nigrostriatal dopaminergic loss of neurons and fibers was occurred by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise alleviated nigrostriatal dopaminergic loss of neurons and fibers in the rotenone-induced Parkinson rats. α-Synuclein expression in the nigrostriatum was enhanced by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise suppressed α-synuclein expression in the rotenone-induced Parkinson rats. Treadmill exercise improved motor function through preservation of nigrostriatal dopaminergic neurons and fibers and suppression of nigrostriatal formation of Lewy bodies in rotenone-induced Parkinson rats.

Keywords: Parkinson disease; Rotenone; Striatum; Substantia nigra; Treadmill exercise

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