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Ambler BR, Yang MH, Altman RA. Metal-catalyzed Decarboxylative Fluoroalkylation Reactions. Synlett. 2016;27(20):2747-2755doi: 10.1055/s-0036-1588637.
Ambler, B. R., Yang, M. H., & Altman, R. A. (2016). Metal-catalyzed Decarboxylative Fluoroalkylation Reactions. Synlett : accounts and rapid communications in synthetic organic chemistry, 27(20), 2747-2755. https://doi.org/10.1055/s-0036-1588637
Ambler, Brett R, et al. "Metal-catalyzed Decarboxylative Fluoroalkylation Reactions." Synlett : accounts and rapid communications in synthetic organic chemistry vol. 27,20 (2016): 2747-2755. doi: https://doi.org/10.1055/s-0036-1588637
Ambler BR, Yang MH, Altman RA. Metal-catalyzed Decarboxylative Fluoroalkylation Reactions. Synlett. 2016 Dec;27(20):2747-2755. doi: 10.1055/s-0036-1588637. PMID: 28260839; PMCID: PMC5330304.
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Synlett. 2016 Dec;27(20):2747-2755. doi: 10.1055/s-0036-1588637.

Metal-catalyzed Decarboxylative Fluoroalkylation Reactions.

Synlett : accounts and rapid communications in synthetic organic chemistry

Brett R Ambler, Ming-Hsiu Yang, Ryan A Altman

Affiliations

  1. Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.

PMID: 28260839 PMCID: PMC5330304 DOI: 10.1055/s-0036-1588637

Abstract

Metal-catalyzed decarboxylative fluoroalkylation reactions enable the conversion of simple O-based substrates into biologically relevant fluorinated analogs. Herein, we present decarboxylative methods that facilitate the synthesis of trifluoromethyl- and difluoroketone-containing products. We highlight key mechanistic aspects that are critical for efficient catalysis, and that inspired our thinking while developing the reactions.

Keywords: Catalysis; Copper; Decarboxylation; Difluoroketone; Fluorine; Palladium; Trifluoromethylation

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