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Diaz Orea MA, Muñoz Perez V, Gómez Conde E, et al. Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients. Asian Pac J Cancer Prev. 2017;18(2):577-582doi: 10.22034/APJCP.2017.18.2.577.
Diaz Orea, M. A., Muñoz Perez, V., Gómez Conde, E., Castellanos Sánchez, V. O., Gonzalez Lopez, R., Flores Alonso, J. C., Cárdenas, M. E., Galicia, A. L., & Mendoza, A. (2017). Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients. Asian Pacific journal of cancer prevention : APJCP, 18(2), 577-582. https://doi.org/10.22034/APJCP.2017.18.2.577
Diaz Orea, Maria Alicia, et al. "Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients." Asian Pacific journal of cancer prevention : APJCP vol. 18,2 (2017): 577-582. doi: https://doi.org/10.22034/APJCP.2017.18.2.577
Diaz Orea MA, Muñoz Perez V, Gómez Conde E, Castellanos Sánchez VO, Gonzalez Lopez R, Flores Alonso JC, Cárdenas ME, Galicia AL, Mendoza A. Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients. Asian Pac J Cancer Prev. 2017 Feb 01;18(2):577-582. doi: 10.22034/APJCP.2017.18.2.577. PMID: 28350427; PMCID: PMC5454761.
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Asian Pac J Cancer Prev. 2017 Feb 01;18(2):577-582. doi: 10.22034/APJCP.2017.18.2.577.

Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients.

Asian Pacific journal of cancer prevention : APJCP

Maria Alicia Diaz Orea, Veronica Muñoz Perez, Eduardo Gómez Conde, Victor Omar Castellanos Sánchez, Rogelio Gonzalez Lopez, J Carlos Flores Alonso, M Elena Cárdenas, A Luisa Galicia, Aurelio Mendoza

Affiliations

  1. Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico. Email: [email protected]

PMID: 28350427 PMCID: PMC5454761 DOI: 10.22034/APJCP.2017.18.2.577

Abstract

Objective: In this study, expression of Interleukin-2, Interleukin-4, Interleukin-10 and transforming growth factor beta in diffuse and intestinal type gastric cancers from Mexican patients was assessed for use as markers of malignancy. Methods: A total of 30 biopsies from gastric adenocarcinomas, 60% diffuse, 20% intestinal and 20% mixed in type, were studied by immunohistochemistry. Results: Regarding expression of cytokines, 23% were positive for IL-2, 26.7% for IL-4, 16.6% for IL-10 and none for TGF-β. There were found Significant statistically stage differences were noted.For example, for stages I-II 100% were IL-2 positive (p = 0.009), 87.5% were IL-4 positive (p = 0.005) and 100.0% IL-10 positive (p = 0.009). Young women were more likely to suffer gastric adenocarcinoma. In biopsies of male patients with gastric cancer, there was an increased expression of IL-2 and in biopsies from female patients in IL4. There was significantly greater detection of IL-4 and IL-10 expression in stages I and II than in stages III and IV. It was also found that IL-4, IL-10 had a higher positive expression in patients biopsies with low-level differentiations than patients with well differentiated gastric cancer in which cases were undetected. Conclusions: These results suggest that positive expression of IL-4 and IL-10 may be useful as a molecular marker to distinguish stage I and II diffuse gastric cancers which can be more readily controlled.

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Keywords: Gastric adenocarcinoma; Cytokines; IL2; IL4; IL10; TGFβ

References

  1. Science. 2013 Jan 18;339(6117):286-91 - PubMed
  2. Crit Rev Oncog. 1993;4(5):493-540 - PubMed
  3. Cancer Gene Ther. 2008 Jan;15(1):51-9 - PubMed
  4. Tumour Biol. 2014 Aug;35(8):8301-7 - PubMed
  5. J Clin Immunol. 1992 Jul;12(4):239-47 - PubMed
  6. J Pathol. 2015 Nov;237(3):319-29 - PubMed
  7. World J Gastroenterol. 2010 Mar 7;16(9):1129-37 - PubMed
  8. Acta Pathol Microbiol Scand. 1965;64:31-49 - PubMed
  9. Front Physiol. 2014 Mar 05;5:75 - PubMed
  10. CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 - PubMed
  11. Annu Rev Immunol. 2001;19:683-765 - PubMed
  12. Cancer Microenviron. 2013 Aug;6(2):117-22 - PubMed
  13. Cancer Res. 1995 Dec 1;55(23):5545-7 - PubMed
  14. Hepatology. 2013 Mar;57(3):1107-16 - PubMed
  15. Gastric Cancer. 2007;10(2):75-83 - PubMed
  16. J Vet Diagn Invest. 1991 Jan;3(1):101-12 - PubMed
  17. Hepatology. 2010 Jan;51(1):154-64 - PubMed
  18. Curr Opin Immunol. 2010 Apr;22(2):231-7 - PubMed
  19. N Engl J Med. 1994 Nov 10;331(19):1286-92 - PubMed
  20. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7708-12 - PubMed
  21. Annu Rev Immunol. 1998;16:137-61 - PubMed
  22. Cell J. 2013 Spring;15(1):11-8 - PubMed
  23. J Biol Chem. 1994 Oct 21;269(42):26449-55 - PubMed
  24. J Biomed Biotechnol. 2010;2010:901564 - PubMed
  25. J Exp Med. 2015 Aug 24;212(9):1433-48 - PubMed
  26. Br J Cancer. 1998 Nov;78(10):1373-8 - PubMed
  27. Genes Dev. 2006 Mar 1;20(5):543-56 - PubMed
  28. Salud Publica Mex. 2001 Jul-Aug;43(4):340-51 - PubMed
  29. New Horiz Transl Med. 2016 Jan;3(1):9-21 - PubMed
  30. Cancer. 1999 Nov 15;86(10):1936-43 - PubMed
  31. Immunity. 2013 Oct 17;39(4):782-95 - PubMed
  32. Curr Opin Rheumatol. 2002 Nov;14(6):681-5 - PubMed
  33. Lancet Infect Dis. 2006 Sep;6(9):557-69 - PubMed
  34. Int J Cancer. 2010 Dec 15;127(12):2893-917 - PubMed
  35. Gastroenterology. 1997 Jan;112(1):33-9 - PubMed
  36. Nat Rev Cancer. 2012 Mar 15;12 (4):298-306 - PubMed
  37. Asian Pac J Cancer Prev. 2011;12(7):1803-6 - PubMed
  38. Cancer Cell. 2009 Aug 4;16(2):91-102 - PubMed
  39. J Hepatol. 2009 May;50(5):980-9 - PubMed
  40. Gut Liver. 2014 Mar;8(2):131-9 - PubMed
  41. Cell. 2006 Jan 27;124(2):263-6 - PubMed
  42. J Gastrointest Oncol. 2012 Sep;3(3):251-61 - PubMed
  43. Cell. 2010 Apr 2;141(1):39-51 - PubMed
  44. Int J Oncol. 1998 Apr;12(4):847-51 - PubMed
  45. J Clin Invest. 2014 Oct;124(10):4657-67 - PubMed
  46. Int J Mol Med. 2010 Sep;26(3):325-32 - PubMed
  47. Asian Pac J Cancer Prev. 2013;14(4):2577-82 - PubMed
  48. NPJ Breast Cancer. 2016;2:null - PubMed

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