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Khoza S, Moyo I, Ncube D. Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats. J Toxicol. 2017;2017:6746989doi: 10.1155/2017/6746989.
Khoza, S., Moyo, I., & Ncube, D. (2017). Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats. Journal of toxicology, 20176746989. https://doi.org/10.1155/2017/6746989
Khoza, Star, et al. "Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats." Journal of toxicology vol. 2017 (2017): 6746989. doi: https://doi.org/10.1155/2017/6746989
Khoza S, Moyo I, Ncube D. Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats. J Toxicol. 2017;2017:6746989. doi: 10.1155/2017/6746989. Epub 2017 Feb 05. PMID: 28261269; PMCID: PMC5316457.
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J Toxicol. 2017;2017:6746989. doi: 10.1155/2017/6746989. Epub 2017 Feb 05.

Comparative Hepatotoxicity of Fluconazole, Ketoconazole, Itraconazole, Terbinafine, and Griseofulvin in Rats.

Journal of toxicology

Star Khoza, Ishmael Moyo, Denver Ncube

Affiliations

  1. Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
  2. Department of Anatomy, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

PMID: 28261269 PMCID: PMC5316457 DOI: 10.1155/2017/6746989

Abstract

Oral ketoconazole was recently the subject of regulatory safety warnings because of its association with increased risk of inducing hepatic injury. However, the relative hepatotoxicity of antifungal agents has not been clearly established. The aim of this study was to compare the hepatotoxicity induced by five commonly prescribed oral antifungal agents. Rats were treated with therapeutic oral doses of griseofulvin, fluconazole, itraconazole, ketoconazole, and terbinafine. After 14 days, only ketoconazole had significantly higher ALT levels (

Conflict of interest statement

The authors declare that there are no competing interests.

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