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Lopalco G, Lucherini OM, Lopalco A, et al. Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease. Front Immunol. 2017;8:200doi: 10.3389/fimmu.2017.00200.
Lopalco, G., Lucherini, O. M., Lopalco, A., Venerito, V., Fabiani, C., Frediani, B., Galeazzi, M., Lapadula, G., Cantarini, L., & Iannone, F. (2017). Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease. Frontiers in immunology, 8200. https://doi.org/10.3389/fimmu.2017.00200
Lopalco, Giuseppe, et al. "Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease." Frontiers in immunology vol. 8 (2017): 200. doi: https://doi.org/10.3389/fimmu.2017.00200
Lopalco G, Lucherini OM, Lopalco A, Venerito V, Fabiani C, Frediani B, Galeazzi M, Lapadula G, Cantarini L, Iannone F. Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease. Front Immunol. 2017 Feb 27;8:200. doi: 10.3389/fimmu.2017.00200. eCollection 2017. PMID: 28289419; PMCID: PMC5327443.
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Front Immunol. 2017 Feb 27;8:200. doi: 10.3389/fimmu.2017.00200. eCollection 2017.

Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease.

Frontiers in immunology

Giuseppe Lopalco, Orso Maria Lucherini, Antonio Lopalco, Vincenzo Venerito, Claudia Fabiani, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Luca Cantarini, Florenzo Iannone

Affiliations

  1. Department of Emergency and Organ Transplantation, Rheumatology Unit, University of Bari Aldo Moro , Bari , Italy.
  2. Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Siena , Italy.
  3. Department of Pharmaceutical Chemistry, University of Bari , Bari , Italy.
  4. Department of Ophthalmology, Humanitas Research Hospital , Milan , Italy.

PMID: 28289419 PMCID: PMC5327443 DOI: 10.3389/fimmu.2017.00200

Abstract

Behçet's disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC). The secondary goal was to evaluate potential correlations between these putative circulating biomarkers, the status of disease activity, and the specific organ involvement at the time of sample collection. Fifty-four serum samples were collected from 46 BD patients (17 males, 29 females, mean age 45.5 ± 11.3 years), and 19 HC (10 males, 9 females, mean age 43 ± 8.3 years). Twenty-five serum cytokines (APRIL/TNFS13, BAFF/TNFSF13B, sCD30/TNFRSF8, sCD163, Chitinase3-like1, gp130/sIL-6Rb, IFNb, sIL-6Ra, IL-10, IL-11, IL-19, IL-20, IL-26, IL-27 (p28), IL-28A/IFN-lambda2, IL-29/IFN-lambda1, IL-32, IL-34, IL-35, LIGHT/TNFSF-14, Pentraxin-3, sTNF-R1, sTNF-R2, TSLP, and TWEAK/TNFSF-12) were simultaneously quantified using a Bio-Rad cytokine bead arrays. Serum concentration of sTNF-R1 (

Keywords: Behçet’s disease; cytokines; mucocutaneous involvement; ocular disease; signature

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