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Agrawal A, Alharthi A, Vailati-Riboni M, et al. Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows. J Anim Sci Biotechnol. 2017;8:20doi: 10.1186/s40104-017-0150-z.
Agrawal, A., Alharthi, A., Vailati-Riboni, M., Zhou, Z., & Loor, J. J. (2017). Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows. Journal of animal science and biotechnology, 820. https://doi.org/10.1186/s40104-017-0150-z
Agrawal, Alea, et al. "Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows." Journal of animal science and biotechnology vol. 8 (2017): 20. doi: https://doi.org/10.1186/s40104-017-0150-z
Agrawal A, Alharthi A, Vailati-Riboni M, Zhou Z, Loor JJ. Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows. J Anim Sci Biotechnol. 2017 Mar 01;8:20. doi: 10.1186/s40104-017-0150-z. eCollection 2017. PMID: 28261474; PMCID: PMC5331663.
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J Anim Sci Biotechnol. 2017 Mar 01;8:20. doi: 10.1186/s40104-017-0150-z. eCollection 2017.

Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein cows.

Journal of animal science and biotechnology

Alea Agrawal, Abdulrahman Alharthi, Mario Vailati-Riboni, Zheng Zhou, Juan J Loor

Affiliations

  1. Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801 USA.

PMID: 28261474 PMCID: PMC5331663 DOI: 10.1186/s40104-017-0150-z

Abstract

BACKGROUND: G-protein coupled receptors (GPCR), also referred as Free Fatty Acid Receptors (FFAR), are widely studied within human medicine as drug targets for metabolic disorders. To combat metabolic disorders prevalent in dairy cows during the transition period, which co-occur with negative energy balance and changes to lipid and glucose metabolism, it may be helpful to identify locations and roles of FFAR and other members of the GPCR family in bovine tissues.

RESULTS: Quantitative RT-PCR (qPCR) of subcutaneous adipose, liver, and PMNL samples during the transition period (-10, +7, and +20 or +30 d) were used for expression profiling of medium- (MCFA) and long-chain fatty acid (LCFA) receptors

CONCLUSIONS: The data indicate that there is likely not a direct role in liver for the selected GPCR during the transition period, but they do play variable roles in adipose and PMN. In future, these receptors may prove useful targets and/or markers for peripartal metabolism and immunity.

Keywords: Inflammation; Methionine; Neutrophils; Transition cow

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