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Piehl DW, Blancas-Mejía LM, Wall JS, et al. Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS Omega. 2017;2(2):712-720doi: 10.1021/acsomega.6b00494.
Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M., & Rienstra, C. M. (2017). Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS omega, 2(2), 712-720. https://doi.org/10.1021/acsomega.6b00494
Piehl, Dennis W, et al. "Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini." ACS omega vol. 2,2 (2017): 712-720. doi: https://doi.org/10.1021/acsomega.6b00494
Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM. Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27. PMID: 28261692; PMCID: PMC5331457.
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ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27.

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

ACS omega

Dennis W Piehl, Luis M Blancas-Mejía, Jonathan S Wall, Stephen J Kennel, Marina Ramirez-Alvarado, Chad M Rienstra

Affiliations

  1. Department of Biochemistry, Department of Chemistry, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign , 600 S Mathews Avenue, Urbana, Illinois 61801, United States.
  2. Department of Biochemistry and Molecular Biology, Mayo Clinic , 200 First Street SW, Rochester, Minnesota 55905, United States.
  3. Department of Medicine and Department of Radiology, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, Tennessee 37920, United States; Department of Medicine and Department of Radiology, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, Tennessee 37920, United States.
  4. Department of Biochemistry, Department of Chemistry, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, Urbana, Illinois 61801, United States; Department of Biochemistry, Department of Chemistry, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, Urbana, Illinois 61801, United States; Department of Biochemistry, Department of Chemistry, and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 600 S Mathews Avenue, Urbana, Illinois 61801, United States.

PMID: 28261692 PMCID: PMC5331457 DOI: 10.1021/acsomega.6b00494

Abstract

Light-chain (AL)-associated amyloidosis is a systemic disorder involving the formation and deposition of immunoglobulin AL fibrils in various bodily organs. One severe instance of AL disease is exhibited by the patient-derived variable domain (V

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