Display options
Cite
Park HM, Hur YH, Cho CK, et al. Incidence of underlying biliary neoplasm in patients after major hepatectomy for preoperative benign hepatolithiasis. Ann Hepatobiliary Pancreat Surg. 2016;20(4):173-179doi: 10.14701/ahbps.2016.20.4.173.
Park, H. M., Hur, Y. H., Cho, C. K., Koh, Y. S., Kim, H. J., & Park, E. K. (2016). Incidence of underlying biliary neoplasm in patients after major hepatectomy for preoperative benign hepatolithiasis. Annals of hepato-biliary-pancreatic surgery, 20(4), 173-179. https://doi.org/10.14701/ahbps.2016.20.4.173
Park, Hyeong Min, et al. "Incidence of underlying biliary neoplasm in patients after major hepatectomy for preoperative benign hepatolithiasis." Annals of hepato-biliary-pancreatic surgery vol. 20,4 (2016): 173-179. doi: https://doi.org/10.14701/ahbps.2016.20.4.173
Park HM, Hur YH, Cho CK, Koh YS, Kim HJ, Park EK. Incidence of underlying biliary neoplasm in patients after major hepatectomy for preoperative benign hepatolithiasis. Ann Hepatobiliary Pancreat Surg. 2016 Nov;20(4):173-179. doi: 10.14701/ahbps.2016.20.4.173. Epub 2016 Nov 30. PMID: 28261696; PMCID: PMC5325148.
Copy Download .nbib Format: NLM
Share it on

Ann Hepatobiliary Pancreat Surg. 2016 Nov;20(4):173-179. doi: 10.14701/ahbps.2016.20.4.173. Epub 2016 Nov 30.

Incidence of underlying biliary neoplasm in patients after major hepatectomy for preoperative benign hepatolithiasis.

Annals of hepato-biliary-pancreatic surgery

Hyeong Min Park, Young Hoe Hur, Chol Kyoon Cho, Yang Seok Koh, Hee Joon Kim, Eun Kyu Park

Affiliations

  1. Department of Surgery, Chonnam National University College of Medicine, Hwasun, Korea.

PMID: 28261696 PMCID: PMC5325148 DOI: 10.14701/ahbps.2016.20.4.173

Abstract

BACKGROUNDS/AIMS: Despite hepatolithiasis being a risk factor for biliary neoplasm including cholangiocarcinoma, the incidence of underlying biliary neoplasm is unknown in patients with preoperative benign hepatolithiasis. The aim of this study was to evaluate the incidence of underlying biliary neoplasm in patients who underwent major hepatectomy for preoperative benign hepatolithiasis.

METHODS: Between March 2005 and December 2015, 73 patients who underwent major hepatectomy for preoperative benign hepatolithiasis were enrolled in this study. The incidence and pathological differentiation of concomitant biliary neoplasm were retrospectively determined by review of medical records. Postoperative complications after major hepatectomy were evaluated.

RESULTS: Concomitant biliary neoplasm was pathologically confirmed in 20 patients (27.4%). Biliary intraepithelial neoplasia (BIN) was detected in 12 patients (16.4%), and 1 patient (1.4%) had intraductal papillary mucinous neoplasm (IPMN), as the premalignant lesion. Cholangiocarcinoma was pathologically confirmed in 7 patients (9.6%). Preoperative imaging of the 73 patients revealed biliary stricture at the first branch of bile duct in 31 patients (42.5%), and at the second branch of bile duct in 39 patients (53.4%). Postoperative complications developed in 14 patients (19.1%). Almost all patients recovered from complications, including intra-abdominal abscess (9.6%), bile leakage (4.1%), pleural effusion (2.7%), and wound infection (1.4%). Only 1 patient (1.4%) died from aspiration pneumonia.

CONCLUSIONS: The incidence of underlying biliary neoplasm was not negligible in the patients with hepatolithiasis, despite meticulous preoperative evaluations.

Keywords: Biliary neoplasm; Cholangiocarcinoma; Hepatolithiasis; Major hepatectomy

References

  1. Cancer. 1991 Nov 15;68(10):2217-23 - PubMed
  2. Gastroenterology. 2013 Dec;145(6):1215-29 - PubMed
  3. J Am Coll Surg. 2013 Oct;217(4):736-750.e4 - PubMed
  4. J Hepatol. 2006 Feb;44(2):350-8 - PubMed
  5. Virchows Arch A Pathol Anat Histopathol. 1985;406(1):45-58 - PubMed
  6. World J Surg. 2007 Mar;31(3):479-82 - PubMed
  7. J Hepatobiliary Pancreat Sci. 2014 Sep;21(9):617-22 - PubMed
  8. Surgery. 2004 Apr;135(4):386-93 - PubMed
  9. Eur J Med Res. 2010 Aug 20;15(8):357-61 - PubMed
  10. Nat Rev Gastroenterol Hepatol. 2011 Aug 02;8(9):512-22 - PubMed
  11. World J Surg. 2015 Jun;39(6):1537-42 - PubMed
  12. Surgery. 1999 Sep;126(3):484-91 - PubMed
  13. Nat Rev Gastroenterol Hepatol. 2012 Dec;9(12):732-7 - PubMed
  14. Hepatology. 2011 Jul;54(1):173-84 - PubMed
  15. Br J Surg. 1992 Jul;79(7):663-6 - PubMed
  16. World J Gastroenterol. 2013 Jan 21;19(3):375-80 - PubMed
  17. Surg Laparosc Endosc Percutan Tech. 2000 Oct;10(5):278-83 - PubMed
  18. World J Surg. 1990 Sep-Oct;14(5):587-92; discussion 592-3 - PubMed
  19. J Hepatobiliary Pancreat Surg. 2005;12 (6):463-6 - PubMed
  20. Eur J Surg Oncol. 2005 Dec;31(10):1175-9 - PubMed
  21. Surgery. 2000 May;127(5):493-7 - PubMed
  22. HPB Surg. 1995;9(1):37-41 - PubMed
  23. J Am Coll Surg. 1999 Aug;189(2):177-82 - PubMed
  24. Surgery. 2009 Nov;146(5):843-53 - PubMed
  25. Hepatol Res. 2012 Feb;42(2):166-70 - PubMed
  26. Am J Surg. 2009 Aug;198(2):199-202 - PubMed
  27. Ann R Coll Surg Engl. 2006 Jul;88(4):383-9 - PubMed
  28. Ann Surg. 1999 Mar;229(3):322-30 - PubMed
  29. Dig Surg. 2013;30(4-6):309-16 - PubMed
  30. Gastrointest Endosc. 1995 Jul;42(1):13-8 - PubMed
  31. Liver Int. 2007 Nov;27(9):1174-84 - PubMed
  32. Gastrointest Endosc. 2001 Mar;53(3):318-23 - PubMed
  33. Surgery. 1996 Sep;120(3):509-14 - PubMed
  34. HPB (Oxford). 2008;10(2):87-93 - PubMed
  35. J Surg Oncol. 2006 Sep 15;94(4):338-43 - PubMed
  36. Gut. 2002 Nov;51 Suppl 6:VI1-9 - PubMed

Publication Types