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McCulloch D, Brown C, Iland H. Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives. Onco Targets Ther. 2017;10:1585-1601doi: 10.2147/OTT.S100513.
McCulloch, D., Brown, C., & Iland, H. (2017). Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives. OncoTargets and therapy, 101585-1601. https://doi.org/10.2147/OTT.S100513
McCulloch, Derek, et al. "Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives." OncoTargets and therapy vol. 10 (2017): 1585-1601. doi: https://doi.org/10.2147/OTT.S100513
McCulloch D, Brown C, Iland H. Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives. Onco Targets Ther. 2017 Mar 14;10:1585-1601. doi: 10.2147/OTT.S100513. eCollection 2017. PMID: 28352191; PMCID: PMC5359123.
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Onco Targets Ther. 2017 Mar 14;10:1585-1601. doi: 10.2147/OTT.S100513. eCollection 2017.

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives.

OncoTargets and therapy

Derek McCulloch, Christina Brown, Harry Iland

Affiliations

  1. Institute of Hematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

PMID: 28352191 PMCID: PMC5359123 DOI: 10.2147/OTT.S100513

Abstract

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a unique morphological appearance, associated coagulopathy and canonical balanced translocation of genetic material between chromosomes 15 and 17. APL was first described as a distinct subtype of AML in 1957 by Dr Leif Hillestad who recognized the pattern of an acute leukemia associated with fibrinolysis, hypofibrinogenemia and catastrophic hemorrhage. In the intervening years, the characteristic morphology of APL has been described fully with both classical hypergranular and variant microgranular forms. Both are characterized by a balanced translocation between the long arms of chromosomes 15 and 17, [t(15;17)(q24;q21)], giving rise to a unique fusion gene

Keywords: ATRA; acute promyelocytic leukemia; arsenic trioxide

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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