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Sameer AS, Syeed N, Tak SA, et al. ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population. Cardiol Res. 2010;1(1):1-7doi: 10.4021/cr101e.
Sameer, A. S., Syeed, N., Tak, S. A., Bashir, S., Nissar, S., & Siddiqi, M. A. (2010). ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population. Cardiology research, 1(1), 1-7. https://doi.org/10.4021/cr101e
Sameer, A Syed, et al. "ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population." Cardiology research vol. 1,1 (2010): 1-7. doi: https://doi.org/10.4021/cr101e
Sameer AS, Syeed N, Tak SA, Bashir S, Nissar S, Siddiqi MA. ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population. Cardiol Res. 2010 Dec;1(1):1-7. doi: 10.4021/cr101e. Epub 2010 Nov 20. PMID: 28352369; PMCID: PMC5358231.
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Cardiol Res. 2010 Dec;1(1):1-7. doi: 10.4021/cr101e. Epub 2010 Nov 20.

ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population.

Cardiology research

A Syed Sameer, Nidda Syeed, Shahid A Tak, Samina Bashir, Saniya Nissar, Mushtaq A Siddiqi

Affiliations

  1. Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India; Departments of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
  2. Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.
  3. Departments of Cardiology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
  4. Department of Clinical Biochemistry, Kashmri University, Hazratbal, Srinagar, Kashmir, India.
  5. Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India; Department of Clinical Biochemistry, Kashmri University, Hazratbal, Srinagar, Kashmir, India.

PMID: 28352369 PMCID: PMC5358231 DOI: 10.4021/cr101e

Abstract

BACKGROUND: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population.

MATERIALS AND METHODS: We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fisher's Chi square test was used for calculation of P value and OR.

RESULTS: We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases.

CONCLUSIONS: The ACE I/D genotype is positively associated with hypertension in our population.

Keywords: ACE; Hypertension; Kashmir; Polymorphism; RFLP

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