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Zhu ZQ, Shen Y, Liu JX, et al. Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis. Org Lett. 2017;19(7):1542-1545doi: 10.1021/acs.orglett.7b00351.
Zhu, Z. Q., Shen, Y., Liu, J. X., Tao, J. Y., & Shi, F. (2017). Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis. Organic letters, 19(7), 1542-1545. https://doi.org/10.1021/acs.orglett.7b00351
Zhu, Zi-Qi, et al. "Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis." Organic letters vol. 19,7 (2017): 1542-1545. doi: https://doi.org/10.1021/acs.orglett.7b00351
Zhu ZQ, Shen Y, Liu JX, Tao JY, Shi F. Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis. Org Lett. 2017 Apr 07;19(7):1542-1545. doi: 10.1021/acs.orglett.7b00351. Epub 2017 Mar 14. PMID: 28290202.
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Org Lett. 2017 Apr 07;19(7):1542-1545. doi: 10.1021/acs.orglett.7b00351. Epub 2017 Mar 14.

Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis.

Organic letters

Zi-Qi Zhu, Yang Shen, Jin-Xi Liu, Ji-Yu Tao, Feng Shi

Affiliations

  1. School of Chemistry and Material Science, Jiangsu Normal University , Xuzhou 221116, China.

PMID: 28290202 DOI: 10.1021/acs.orglett.7b00351

Abstract

The first catalytic asymmetric α-arylation of pyrazol-5-ones has been established by using 2-indolylmethanols as direct electrophilic arylation reagents under the cooperative catalysis of Pd(0) and a chiral phosphoric acid, which afforded the α-arylation products of pyrazol-5-ones in generally high yields and good enantioselectivities (up to 99% yield, >99% ee).

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