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Hartopo AB, Setianto BY, Gharini PP, et al. On Arrival High Blood Glucose Level is Associated With Detrimental and Fatal Hospitalization Outcomes for Acute Coronary Syndrome. Cardiol Res. 2011;2(4):160-167doi: 10.4021/cr56w.
Hartopo, A. B., Setianto, B. Y., Gharini, P. P., & Dinarti, L. K. (2011). On Arrival High Blood Glucose Level is Associated With Detrimental and Fatal Hospitalization Outcomes for Acute Coronary Syndrome. Cardiology research, 2(4), 160-167. https://doi.org/10.4021/cr56w
Hartopo, Anggoro B, et al. "On Arrival High Blood Glucose Level is Associated With Detrimental and Fatal Hospitalization Outcomes for Acute Coronary Syndrome." Cardiology research vol. 2,4 (2011): 160-167. doi: https://doi.org/10.4021/cr56w
Hartopo AB, Setianto BY, Gharini PP, Dinarti LK. On Arrival High Blood Glucose Level is Associated With Detrimental and Fatal Hospitalization Outcomes for Acute Coronary Syndrome. Cardiol Res. 2011 Aug;2(4):160-167. doi: 10.4021/cr56w. Epub 2011 Jul 25. PMID: 28352385; PMCID: PMC5358223.
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Cardiol Res. 2011 Aug;2(4):160-167. doi: 10.4021/cr56w. Epub 2011 Jul 25.

On Arrival High Blood Glucose Level is Associated With Detrimental and Fatal Hospitalization Outcomes for Acute Coronary Syndrome.

Cardiology research

Anggoro B Hartopo, Budi Y Setianto, Putrika P R Gharini, Lucia K Dinarti

Affiliations

  1. Department of Cardiology and Vascular Medicine, School of Medicine Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia.

PMID: 28352385 PMCID: PMC5358223 DOI: 10.4021/cr56w

Abstract

BACKGROUND: High blood glucose level is frequently encountered in acute coronary syndrome. We investigated the effects of high blood glucose measured on arrival on hospitalization adverse events in acute coronary syndrome. Our study patients were Javanese in ethnicity, which constitute half of population in Indonesia. We hypothesized that elevated blood glucose has detrimental effects on hospitalization for acute coronary syndrome.

METHODS: We designed an observasional cohort study and recruited 148 consecutive patients with acute coronary syndrome. Venous blood was collected on hospital arrival. High blood glucose level was determined as plasma glucose > 140 mg/dL. Adverse hospitalization events were recorded, i.e. mortality, acute heart failure, cardiogenic shock and heart rhythm disorders. Echocardiography examination was performed to determine left ventricular function.

RESULTS: The prevalence of on arrival high blood glucose among Javanese patients with acute coronary syndrome was considerably high (36%). On arrival high blood glucose was associated with acute heart failure (P < 0.001) and shock cardiogenic (P = 0.02). Heart rhythm disorders were higher in high blood glucose patients (P = 0.004). Left ventricular dysfunction was more prevalent in high blood glucose patients (P = 0.001) and ejection fraction was lower (P = 0.001). On arrival high blood glucose was independently associated with hospitalization adverse events (adjusted odds ratio = 2.3, 95% confidence interval: 1.1-4.9, P = 0.03) and hospital mortality (adjusted odds ratio = 6.9, 95% confidence interval: 1.2-38.6, P = 0.03).

CONCLUSIONS: Our study suggests that on arrival high blood glucose among Javanese patients with acute coronary syndrome is considerably high and is associated with detrimental and fatal hospitalization outcomes.

Keywords: Acute coronary syndrome; Glucose; Hospitalization adverse events; Mortality

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