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Skoczyńska A, Turczyn B, Wojakowska A, et al. Postprandial decrease in LDL-cholesterol in men with metabolic syndrome. Open Med (Wars). 2015;10(1):138-151doi: 10.1515/med-2015-0025.
Skoczyńska, A., Turczyn, B., Wojakowska, A., Kreczyńska, B., Skoczyńska, M., & Wojtas, K. (2015). Postprandial decrease in LDL-cholesterol in men with metabolic syndrome. Open medicine (Warsaw, Poland), 10(1), 138-151. https://doi.org/10.1515/med-2015-0025
Skoczyńska, Anna, et al. "Postprandial decrease in LDL-cholesterol in men with metabolic syndrome." Open medicine (Warsaw, Poland) vol. 10,1 (2015): 138-151. doi: https://doi.org/10.1515/med-2015-0025
Skoczyńska A, Turczyn B, Wojakowska A, Kreczyńska B, Skoczyńska M, Wojtas K. Postprandial decrease in LDL-cholesterol in men with metabolic syndrome. Open Med (Wars). 2015 Feb 03;10(1):138-151. doi: 10.1515/med-2015-0025. eCollection 2015. PMID: 28352689; PMCID: PMC5153088.
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Open Med (Wars). 2015 Feb 03;10(1):138-151. doi: 10.1515/med-2015-0025. eCollection 2015.

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome.

Open medicine (Warsaw, Poland)

Anna Skoczyńska, Barbara Turczyn, Anna Wojakowska, Bogusława Kreczyńska, Marta Skoczyńska, Kamila Wojtas

Affiliations

  1. Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wroc?aw, Poland, tel.: 71-7364005, fax: 71-7364009.
  2. Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wroc?aw, Poland.

PMID: 28352689 PMCID: PMC5153088 DOI: 10.1515/med-2015-0025

Abstract

BACKGROUND: In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy).

METHODS: 36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apolipoproteins A-I, B, and hsCRP immunoturbidimetrically.

RESULTS: The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-cholesterol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy.

CONCLUSION: In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.

Keywords: Postprandial LDL-cholesterol; apoB/apoA ratio; metabolic syndrome

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