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Nozari A, Berezovski MV. Aptamers for CD Antigens: From Cell Profiling to Activity Modulation. Mol Ther Nucleic Acids. 2016;6:29-44doi: 10.1016/j.omtn.2016.12.002.
Nozari, A., & Berezovski, M. V. (2017). Aptamers for CD Antigens: From Cell Profiling to Activity Modulation. Molecular therapy. Nucleic acids, 629-44. https://doi.org/10.1016/j.omtn.2016.12.002
Nozari, Amin, and Berezovski, Maxim V. "Aptamers for CD Antigens: From Cell Profiling to Activity Modulation." Molecular therapy. Nucleic acids vol. 6 (2017): 29-44. doi: https://doi.org/10.1016/j.omtn.2016.12.002
Nozari A, Berezovski MV. Aptamers for CD Antigens: From Cell Profiling to Activity Modulation. Mol Ther Nucleic Acids. 2017 Mar 17;6:29-44. doi: 10.1016/j.omtn.2016.12.002. Epub 2016 Dec 10. PMID: 28325295; PMCID: PMC5363458.
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Mol Ther Nucleic Acids. 2017 Mar 17;6:29-44. doi: 10.1016/j.omtn.2016.12.002. Epub 2016 Dec 10.

Aptamers for CD Antigens: From Cell Profiling to Activity Modulation.

Molecular therapy. Nucleic acids

Amin Nozari, Maxim V Berezovski

Affiliations

  1. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N6N5, Canada.
  2. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N6N5, Canada. Electronic address: [email protected].

PMID: 28325295 PMCID: PMC5363458 DOI: 10.1016/j.omtn.2016.12.002

Abstract

Nucleic acid-based aptamers are considered to be a promising alternative to antibodies because of their strong and specific binding to diverse targets, fast and inexpensive chemical synthesis, and easy labeling with a fluorescent dye or therapeutic agent. Cluster of differentiation (CD) proteins are among the most popular antigens for aptamers on the cell surface. These anti-CD aptamers could be used in cell biology and biomedicine, from simple cell phenotyping by flow cytometry or fluorescent microscopy to diagnosis and treatment of HIV/AIDS to cancer and immune therapies. The unique feature of aptamers is that they can act simultaneously as an agonist and antagonist of CD receptors depending on a degree of aptamer oligomerization. Aptamers can also deliver small interfering RNA to silence vital genes in CD-positive cells. In this review, we summarize nucleic acid sequences of anti-CD aptamers and their use, which have been validated in multiple studies.

Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Keywords: aptamers; cell imaging; cluster of differentiation; drug delivery; siRNA

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