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Hendrayana T, Wilmer A, Kurth V, et al. Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application. Sci Pharm. 2017;85(1)doi: 10.3390/scipharm85010008.
Hendrayana, T., Wilmer, A., Kurth, V., Schmidt-Wolf, I. G., & Jaehde, U. (2017). Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application. Scientia pharmaceutica, 85(1), . https://doi.org/10.3390/scipharm85010008
Hendrayana, Tomi, et al. "Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application." Scientia pharmaceutica vol. 85,1 (2017). doi: https://doi.org/10.3390/scipharm85010008
Hendrayana T, Wilmer A, Kurth V, Schmidt-Wolf IG, Jaehde U. Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application. Sci Pharm. 2017 Feb 27;85(1). doi: 10.3390/scipharm85010008. PMID: 28264440; PMCID: PMC5388145.
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Sci Pharm. 2017 Feb 27;85(1). doi: 10.3390/scipharm85010008.

Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application.

Scientia pharmaceutica

Tomi Hendrayana, André Wilmer, Verena Kurth, Ingo Gh Schmidt-Wolf, Ulrich Jaehde

Affiliations

  1. Institute of Pharmacy, Clinical Pharmacy, University of Bonn, D-53121 Bonn, Germany. [email protected].
  2. School of Pharmacy, Institut Teknologi Bandung (ITB), Bandung 40132, Indonesia. [email protected].
  3. Institute of Pharmacy, Clinical Pharmacy, University of Bonn, D-53121 Bonn, Germany. [email protected].
  4. Institute of Pharmacy, Clinical Pharmacy, University of Bonn, D-53121 Bonn, Germany. [email protected].
  5. Med. Klinik III und Poliklinik, Center for Integrated Oncology (CIO), University of Bonn, D-53127 Bonn, Germany. [email protected].
  6. Institute of Pharmacy, Clinical Pharmacy, University of Bonn, D-53121 Bonn, Germany. [email protected].

PMID: 28264440 PMCID: PMC5388145 DOI: 10.3390/scipharm85010008

Abstract

Most anticancer agents exhibit a narrow therapeutic index, i.e., a small change in plasma concentrations can lead to a less efficacious treatment or an unacceptable degree of toxicity. This study aimed at providing health professionals with a feasible and time-saving tool to adapt the dose of anticancer agents for patients with renal or hepatic dysfunction. A guideline for anticancer agents was developed based on a literature search. An algorithm was generated to enhance the efficiency of the dose adaptation process. Finally, the dosing guideline was converted into an easy-to-use Excel

Keywords: anticancer; dose adjustment; hepatic dysfunction; renal dysfunction

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