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Seldeen KL, Pang M, Rodríguez-Gonzalez M, et al. A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?. Nutr Metab (Lond). 2017;14:26doi: 10.1186/s12986-017-0174-6.
Seldeen, K. L., Pang, M., Rodríguez-Gonzalez, M., Hernandez, M., Sheridan, Z., Yu, P., & Troen, B. R. (2017). A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?. Nutrition & metabolism, 1426. https://doi.org/10.1186/s12986-017-0174-6
Seldeen, Kenneth L, et al. "A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?." Nutrition & metabolism vol. 14 (2017): 26. doi: https://doi.org/10.1186/s12986-017-0174-6
Seldeen KL, Pang M, Rodríguez-Gonzalez M, Hernandez M, Sheridan Z, Yu P, Troen BR. A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?. Nutr Metab (Lond). 2017 Mar 11;14:26. doi: 10.1186/s12986-017-0174-6. eCollection 2017. PMID: 28293271; PMCID: PMC5346213.
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Nutr Metab (Lond). 2017 Mar 11;14:26. doi: 10.1186/s12986-017-0174-6. eCollection 2017.

A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?.

Nutrition & metabolism

Kenneth L Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu, Bruce R Troen

Affiliations

  1. Division of Geriatrics and Palliative Medicine, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System, Buffalo, NY USA.

PMID: 28293271 PMCID: PMC5346213 DOI: 10.1186/s12986-017-0174-6

Abstract

BACKGROUND: Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m

METHODS: Twenty four-week-old lean and obese male C57BL/6 J mice were fed low, standard, or high levels of cholecalciferol supplementation and followed for 24 weeks. Longitudinal measurements include serum 25-OH and 1,25-(OH)

RESULTS: Baseline serum 25-OH concentrations were not different in lean and obese mice (lean 32.8 ± 4.4 ng/ml versus obese 30.9 ± 1.6 ng/ml p = 0.09). Lean mice receiving low supplementation exhibited rapid declines in serum 25-OH vitamin D concentrations, falling from 33.4 ± 5.4 ng/ml to 14.5 ± 3.4 ng/ml after 2 weeks, while obese mice declined at a lower rate, falling from 30.9 ± 1.5 to 19.0 ± 0.9 ng/ml within the same time period. Surprisingly, high vitamin D

CONCLUSIONS: Low cholecalciferol supplementation in both lean and obese mice significantly and sustainably reduces serum 25-OH vitamin D concentrations. Interestingly, obesity slowed the rate of decline. Over the period of the study, vitamin D insufficiency was not subsequently correlated with greater BMI/body fat, although lean mice with high supplementation consumed greater calories with no apparent BMI increase.

Keywords: BMI; Body Composition; Fat; High fat diet; Insufficiency; Mice; Obesity; PTH; Vitamin D; Weight

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