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Esfahani M, Shabab N, Saidijam M. AdipoRon may be benefit for atherosclerosis prevention. Iran J Basic Med Sci. 2017;20(2):107-109doi: 10.22038/ijbms.2017.8228.
Esfahani, M., Shabab, N., & Saidijam, M. (2017). AdipoRon may be benefit for atherosclerosis prevention. Iranian journal of basic medical sciences, 20(2), 107-109. https://doi.org/10.22038/ijbms.2017.8228
Esfahani, Maryam, et al. "AdipoRon may be benefit for atherosclerosis prevention." Iranian journal of basic medical sciences vol. 20,2 (2017): 107-109. doi: https://doi.org/10.22038/ijbms.2017.8228
Esfahani M, Shabab N, Saidijam M. AdipoRon may be benefit for atherosclerosis prevention. Iran J Basic Med Sci. 2017 Feb;20(2):107-109. doi: 10.22038/ijbms.2017.8228. PMID: 28293385; PMCID: PMC5339649.
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Iran J Basic Med Sci. 2017 Feb;20(2):107-109. doi: 10.22038/ijbms.2017.8228.

AdipoRon may be benefit for atherosclerosis prevention.

Iranian journal of basic medical sciences

Maryam Esfahani, Nooshin Shabab, Massoud Saidijam

Affiliations

  1. Department of Biochemistry and Nutrition, Hamadan University of Medical Sciences, Hamad?n, Iran.
  2. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamad?n, Iran.
  3. Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamad?n, Iran.

PMID: 28293385 PMCID: PMC5339649 DOI: 10.22038/ijbms.2017.8228

Abstract

Atherosclerosis has serious role in coronary arteries disease, so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atherosclerosis development. Some adiponectin effects are mediated by AMPK and PPAR-α signaling. AdipoRon is an orally active synthetic molecule which can bind to AdipoR1, Adipo R2 and activate them. AdipoRon can activate AdipoR1-AMPK- PGC-1α pathway and AdipoR2-PPAR-α pathway. Some studies indicated insulin sensitivity, anti-apoptotic and anti-oxidative effect of AdipoRon. We hypothesize that AdipoRon has anti atherosclerotic effect and may suppress atherosclerosis processes. With confirmation the benefit role of AdipoRon on atherosclerosis, it may be used in patients at risk of atherosclerotic development.

Keywords: AdipoRon; Adiponectin; Adiponectin receptors; Atherosclerosis; Cardiovascular diseases

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