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Gao XP, Qian DW, Xie Z, et al. Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling. Iran J Basic Med Sci. 2017;20(2):131-137doi: 10.22038/ijbms.2017.8235.
Gao, X. P., Qian, D. W., Xie, Z., & Hui, H. (2017). Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling. Iranian journal of basic medical sciences, 20(2), 131-137. https://doi.org/10.22038/ijbms.2017.8235
Gao, Xiao-Peng, et al. "Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling." Iranian journal of basic medical sciences vol. 20,2 (2017): 131-137. doi: https://doi.org/10.22038/ijbms.2017.8235
Gao XP, Qian DW, Xie Z, Hui H. Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling. Iran J Basic Med Sci. 2017 Feb;20(2):131-137. doi: 10.22038/ijbms.2017.8235. PMID: 28293388; PMCID: PMC5339652.
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Iran J Basic Med Sci. 2017 Feb;20(2):131-137. doi: 10.22038/ijbms.2017.8235.

Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.

Iranian journal of basic medical sciences

Xiao-Peng Gao, Dong-Wei Qian, Zhen Xie, Hao Hui

Affiliations

  1. Department of General Surgery, Xi'an Central Hospital, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710003, P.R. China.
  2. Department of Operation Room, Xi'an Central Hospital, The affiliated Xi'an central hospital of Xi'an Jiaotong university College of Medicine, Xi'an 710003, P.R. China.
  3. Department Two of Neurology, Shaanxi Provincial People's Hospital, Xi'an, China.

PMID: 28293388 PMCID: PMC5339652 DOI: 10.22038/ijbms.2017.8235

Abstract

OBJECTIVES: Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an

MATERIALS AND METHODS: An

RESULTS: Treatment with ethanol induced marked cell injury and cell apoptosis in BRL cells. Licochalcone B significantly attenuated ethanol-induced cell injury, and inhibited cell apoptosis. Furthermore, licochalcone B significantly inhibited ethanol-induced intracellular oxidative level, upregulated the expression of p-Erk, and promoted nuclear localization of Nrf2. Additionally, this hepatoprotective role was significantly abolished by inhibition of Erk signaling. However, no apparent effects of Erk inhibition were observed on ethanol-induced hepatotoxicity.

CONCLUSION: This study demonstrates that licochalcone B protects hepatocyte from alcohol-induced cell injury, and this hepatoprotective role might be attributable to apoptosis reduction, inhibition of oxidative stress, and upregulation of Erk-Nrf2. Therefore, licochalcone B might possess potential as a novel therapeutic drug candidate for alcohol-related liver disorders.

Keywords: Alcohol; BRL cells; Erk; Hepatotoxicity; Nrf; Oxidative stress

References

  1. J Dig Dis. 2012 Mar;13(3):133-42 - PubMed
  2. J Hepatol. 2009 Jun;50(6):1258-66 - PubMed
  3. Oxid Med Cell Longev. 2014;2014:134862 - PubMed
  4. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):53-8 - PubMed
  5. J Hepatol. 2007 Aug;47(2):253-61 - PubMed
  6. J Clin Invest. 1999 Sep;104(6):805-13 - PubMed
  7. Oncol Rep. 2014 Nov;32(5):2215-22 - PubMed
  8. Hepatology. 1998 May;27(5):1317-23 - PubMed
  9. Biomed Pharmacother. 2016 Apr;79:35-43 - PubMed
  10. Hepatology. 2005 Jul;42(1):200-7 - PubMed
  11. Cancer Lett. 2011 Mar 1;302(1):69-75 - PubMed
  12. Int Immunopharmacol. 2009 Apr;9(4):499-507 - PubMed
  13. Addiction. 2011 Oct;106(10):1718-24 - PubMed
  14. Food Chem. 2013 Nov 15;141(2):1063-71 - PubMed
  15. Gastroenterology. 2008 Apr;134(4):1159-68 - PubMed
  16. Chem Biol Interact. 2016 Feb 5;245:110-21 - PubMed
  17. Am J Physiol. 1997 Jul;273(1 Pt 1):G7-17 - PubMed
  18. Semin Liver Dis. 2009 May;29(2):222-32 - PubMed
  19. J Hepatol. 2011 Nov;55(5):1159-61 - PubMed
  20. Free Radic Biol Med. 2014 Mar;68:260-7 - PubMed
  21. J Ethnopharmacol. 2011 Jun 14;136(1):168-77 - PubMed
  22. Arch Toxicol. 2014 Sep;88(9):1695-709 - PubMed
  23. Hepatology. 2002 Nov;36(5):1079-88 - PubMed
  24. Gastroenterology. 2011 Nov;141(5):1572-85 - PubMed
  25. J Hepatol. 2006 May;44(5):963-70 - PubMed
  26. Toxicol Appl Pharmacol. 2015 Aug 15;287(1):52-66 - PubMed
  27. Hepatology. 1996 Jan;23(1):155-63 - PubMed
  28. Free Radic Res. 2013 Nov;47(11):894-904 - PubMed
  29. J Mol Med (Berl). 2010 Aug;88(8):829-38 - PubMed
  30. Hepatology. 2014 Apr;59(4):1381-92 - PubMed
  31. Am J Prev Med. 2011 Nov;41(5):516-24 - PubMed
  32. Apoptosis. 2014 Apr;19(4):682-97 - PubMed
  33. Chem Biol Interact. 2014 Dec 5;224:142-8 - PubMed
  34. Toxicol Lett. 2012 Feb 5;208(3):254-61 - PubMed
  35. J Hepatol. 2013 Aug;59(2):387-8 - PubMed
  36. J Ethnopharmacol. 2012 Jun 14;141(3):1071-6 - PubMed

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