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Chan JE, Palakodeti S, Koster MJ. Acute digital ischemia: A rare presentation of antisynthetase syndrome. Eur J Rheumatol. 2017;4(1):63-65doi: 10.5152/eurjrheum.2017.16077.
Chan, J. E., Palakodeti, S., & Koster, M. J. (2017). Acute digital ischemia: A rare presentation of antisynthetase syndrome. European journal of rheumatology, 4(1), 63-65. https://doi.org/10.5152/eurjrheum.2017.16077
Chan, Jin Ei, et al. "Acute digital ischemia: A rare presentation of antisynthetase syndrome." European journal of rheumatology vol. 4,1 (2017): 63-65. doi: https://doi.org/10.5152/eurjrheum.2017.16077
Chan JE, Palakodeti S, Koster MJ. Acute digital ischemia: A rare presentation of antisynthetase syndrome. Eur J Rheumatol. 2017 Mar;4(1):63-65. doi: 10.5152/eurjrheum.2017.16077. Epub 2017 Mar 01. PMID: 28293456; PMCID: PMC5335890.
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Eur J Rheumatol. 2017 Mar;4(1):63-65. doi: 10.5152/eurjrheum.2017.16077. Epub 2017 Mar 01.

Acute digital ischemia: A rare presentation of antisynthetase syndrome.

European journal of rheumatology

Jin Ei Chan, Sandeep Palakodeti, Matthew J Koster

Affiliations

  1. Department of Medicine, Fudan University Shanghai Medical College, Shanghai, China.
  2. Division of Hospital Internal Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Minnesota, USA.
  3. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Minnesota, USA.

PMID: 28293456 PMCID: PMC5335890 DOI: 10.5152/eurjrheum.2017.16077

Abstract

Antisynthetase syndrome (ASS) is recognized as a subgroup of idiopathic inflammatory myopathies (IIMs). It is associated with autoantibodies directed against aminoacyl-transfer ribonucleic acid (tRNA) synthetase enzymes. We report the first case of anti-PL-7/anti-SSA 52kD ASS presenting as acute digital ischemia, an association not described previously. Occlusive vasculopathy is a rare but serious manifestation that can be seen at presentation in patients with ASS and may herald the onset of severe interstitial lung disease (ILD). Comprehensive evaluation should be performed to confirm the presence of subclinical myositis. Extensive myositis-specific antibody testing is strongly recommended even if initial screening autoimmune serologies are unrevealing.

Keywords: Antisynthetase syndrome; angiogram; ischemia; threonine-trna ligase/immunology

Conflict of interest statement

Conflict of Interest: No conflicts of interest was declared by the authors.

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