Display options
Cite
Djordjevic D, Pejovic J, Surbatovic M, et al. Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?. J Med Biochem. 2015;34(4):431-439doi: 10.1515/jomb-2015-0002.
Djordjevic, D., Pejovic, J., Surbatovic, M., Jevdjic, J., Radakovic, S., Veljovic, M., Peric, A., Andjelic, T., & Popovic, N. (2015). Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?. Journal of medical biochemistry, 34(4), 431-439. https://doi.org/10.1515/jomb-2015-0002
Djordjevic, Dragan, et al. "Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?." Journal of medical biochemistry vol. 34,4 (2015): 431-439. doi: https://doi.org/10.1515/jomb-2015-0002
Djordjevic D, Pejovic J, Surbatovic M, Jevdjic J, Radakovic S, Veljovic M, Peric A, Andjelic T, Popovic N. Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?. J Med Biochem. 2015 Oct;34(4):431-439. doi: 10.1515/jomb-2015-0002. Epub 2015 Sep 19. PMID: 28356852; PMCID: PMC4922357.
Copy Download .nbib Format: NLM
Share it on

J Med Biochem. 2015 Oct;34(4):431-439. doi: 10.1515/jomb-2015-0002. Epub 2015 Sep 19.

Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?.

Journal of medical biochemistry

Dragan Djordjevic, Janko Pejovic, Maja Surbatovic, Jasna Jevdjic, Sonja Radakovic, Milic Veljovic, Aneta Peric, Tamara Andjelic, Nada Popovic

Affiliations

  1. Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
  2. Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
  3. Faculty of Medical Sciences, University of Kragujevac, Serbia; Clinical Center Kragujevac, Serbia.
  4. Sector of Preventive Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
  5. Sector for pharmacy, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
  6. Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia.
  7. School of Medicine, University of Belgrade, Serbia; Clinic for Burns, Plastic and Reconstructive Surgery, Belgrade, Serbia.

PMID: 28356852 PMCID: PMC4922357 DOI: 10.1515/jomb-2015-0002

Abstract

BACKGROUND: Severe sepsis and/or trauma complicated by multiple organ dysfunction syndrome are the leading causes of death in critically ill patients. The aim of this prospective single-centre study was to assess the prognostic value and daily trend of interleukin-6 (IL-6), neutrophil CD64 expression, C-reactive protein (CRP) and lipopolysaccharide-binding protein (LBP) regarding outcome in critically ill patients with severe trauma and/or severe sepsis. Outcome measure was hospital mortality.

METHODS: One hundred and two critically ill patients admitted to the intensive care unit of a tertiary university hospital were enrolled in this prospective study. Blood samples were collected on admission (day 1), days 2 and 3.

RESULTS: CD64 index was 1.6-fold higher on day 1 and 1.78-fold higher on day 2 in non-survivors (p<0.05). The area under the curve (AUC) for the CD64 index on day 1 for outcome was 0.727. At a cut-off level of 2.80 sensitivity was 75% and specificity was 65%. Patients with CD64 index level on day 1 higher than 2.80 had 2.4-fold higher probability of dying. Odds ratio is 2.40; 95% CI 0.60-9.67.

CONCLUSIONS: CD64 index on day 1 is a fairly good predictor of outcome. AUCs for IL-6, CRP and LBP were < 0.55, suggesting these biomarkers failed to predict outcome.

Keywords: biomarkers; critical care; leukocytes; outcome; prognosis

References

  1. J Crit Care. 2010 Sep;25(3):542.e1-8 - PubMed
  2. Mediators Inflamm. 2013;2013:362793 - PubMed
  3. Thromb Res. 2008;121(4):499-507 - PubMed
  4. Intensive Care Med. 1999 Jul;25(7):686-96 - PubMed
  5. Lancet. 2006 Jul 8;368(9530):157-69 - PubMed
  6. Crit Care. 2006;10(2):R63 - PubMed
  7. Eur J Clin Microbiol Infect Dis. 2011 Jul;30(7):845-52 - PubMed
  8. Intensive Care Med. 2002 Sep;28(9):1220-5 - PubMed
  9. Clin Exp Immunol. 2001 Aug;125(2):258-65 - PubMed
  10. JAMA. 2011 Dec 21;306(23):2618-9 - PubMed
  11. Med Intensiva. 2012 Nov;36(8):556-62 - PubMed
  12. Biochem Med (Zagreb). 2011;21(3):282-90 - PubMed
  13. PLoS One. 2011;6(8):e23615 - PubMed
  14. ScientificWorldJournal. 2013 Sep 30;2013:961852 - PubMed
  15. Crit Care. 2006;10 (2):R53 - PubMed
  16. Respirology. 2011 Jan;16(1):152-60 - PubMed
  17. J Clin Gastroenterol. 2013 Aug;47(7):637-43 - PubMed
  18. Cytokine. 2006 Dec;36(5-6):283-90 - PubMed
  19. Vojnosanit Pregl. 2001 Mar-Apr;58(2):151-6 - PubMed
  20. Clin Exp Immunol. 2008 Oct;154(1):87-97 - PubMed
  21. J Clin Immunol. 1999 Jul;19(4):203-14 - PubMed
  22. J Immunol Methods. 2006 Apr 20;311(1-2):207-19 - PubMed
  23. Crit Care Med. 2008 Jul;36(7):2014-22 - PubMed
  24. Multidiscip Respir Med. 2012 Nov 21;7(1):47 - PubMed
  25. JAMA. 1993 Dec 22-29;270(24):2957-63 - PubMed
  26. Srp Arh Celok Lek. 2005 Jul-Aug;133(7-8):379-83 - PubMed
  27. Shock. 2006 Jul;26(1):10-2 - PubMed
  28. Mil Med. 2007 Feb;172(2):190-5 - PubMed
  29. J Endotoxin Res. 2006;12(3):151-70 - PubMed
  30. Blood. 1989 Oct;74(5):1704-10 - PubMed
  31. Crit Care. 2011 Jul 15;15(4):R169 - PubMed
  32. Infect Immun. 1995 Jan;63(1):363-5 - PubMed
  33. Eur Cytokine Netw. 2010 Mar;21(1):19-26 - PubMed
  34. PLoS One. 2009 Aug 31;4(8):e6818 - PubMed
  35. Intensive Care Med. 2000 Jul;26(7):883-92 - PubMed
  36. Crit Care Med. 2013 Feb;41(2):580-637 - PubMed
  37. Intensive Care Med. 2000 Mar;26 Suppl 2:S153-8 - PubMed
  38. Arch Pathol Lab Med. 2006 May;130(5):654-61 - PubMed
  39. Crit Care. 2003 Dec;7(6):R154-9 - PubMed
  40. Crit Care Med. 1985 Oct;13(10):818-29 - PubMed

Publication Types