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Wang C, Wang Z, Xie X, et al. Total Synthesis of (±)-Grandilodine B. Org Lett. 2017;19(7):1828-1830doi: 10.1021/acs.orglett.7b00591.
Wang, C., Wang, Z., Xie, X., Yao, X., Li, G., & Zu, L. (2017). Total Synthesis of (±)-Grandilodine B. Organic letters, 19(7), 1828-1830. https://doi.org/10.1021/acs.orglett.7b00591
Wang, Chunyu, et al. "Total Synthesis of (±)-Grandilodine B." Organic letters vol. 19,7 (2017): 1828-1830. doi: https://doi.org/10.1021/acs.orglett.7b00591
Wang C, Wang Z, Xie X, Yao X, Li G, Zu L. Total Synthesis of (±)-Grandilodine B. Org Lett. 2017 Apr 07;19(7):1828-1830. doi: 10.1021/acs.orglett.7b00591. Epub 2017 Mar 15. PMID: 28294627.
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Org Lett. 2017 Apr 07;19(7):1828-1830. doi: 10.1021/acs.orglett.7b00591. Epub 2017 Mar 15.

Total Synthesis of (±)-Grandilodine B.

Organic letters

Chunyu Wang, Zhonglei Wang, Xiaoni Xie, Xiaotong Yao, Guang Li, Liansuo Zu

Affiliations

  1. School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.

PMID: 28294627 DOI: 10.1021/acs.orglett.7b00591

Abstract

The first total synthesis of the opened-type Kopsia alkaloid grandilodine B is reported. Four stereocenters of this alkaloid, three of them quaternary, are stereoselectively generated by a Diels-Alder reaction, a diastereoselective cyanation of tertiary alcohol, and a facial-selective nitrone 1,3-dipolar cycloaddition.

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