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Hara T, Fujiwara Y, Takahashi H, et al. Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report. Surg Case Rep. 2017;3(1):51doi: 10.1186/s40792-017-0326-y.
Hara, T., Fujiwara, Y., Takahashi, H., Sugimura, K., Moon, J. H., Omori, T., Miyoshi, N., Tomokuni, A., Akita, H., Kobayashi, S., Yasui, M., Miyata, H., Ohue, M., Sakon, M., Tomita, Y., & Yano, M. (2017). Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report. Surgical case reports, 3(1), 51. https://doi.org/10.1186/s40792-017-0326-y
Hara, Takeo, et al. "Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report." Surgical case reports vol. 3,1 (2017): 51. doi: https://doi.org/10.1186/s40792-017-0326-y
Hara T, Fujiwara Y, Takahashi H, Sugimura K, Moon JH, Omori T, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Yasui M, Miyata H, Ohue M, Sakon M, Tomita Y, Yano M. Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report. Surg Case Rep. 2017 Dec;3(1):51. doi: 10.1186/s40792-017-0326-y. Epub 2017 Mar 30. PMID: 28357816; PMCID: PMC5371532.
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Surg Case Rep. 2017 Dec;3(1):51. doi: 10.1186/s40792-017-0326-y. Epub 2017 Mar 30.

Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report.

Surgical case reports

Takeo Hara, Yoshiyuki Fujiwara, Hidenori Takahashi, Keijiro Sugimura, Jeong-Ho Moon, Takeshi Omori, Norikatsu Miyoshi, Akira Tomokuni, Hirofumi Akita, Shogo Kobayashi, Masayoshi Yasui, Hiroshi Miyata, Masayuki Ohue, Masato Sakon, Yasuhiko Tomita, Masahiko Yano

Affiliations

  1. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka City, Osaka, 537-8511, Japan.
  2. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka City, Osaka, 537-8511, Japan. [email protected].
  3. Department of Diagnostic Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka City, Osaka, 537-8511, Japan.

PMID: 28357816 PMCID: PMC5371532 DOI: 10.1186/s40792-017-0326-y

Abstract

BACKGROUND: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were treated with surgery and transcatheter arterial chemoembolization (TACE) that later recurred in the stomach.

CASE PRESENTATION: A 45-year-old female with severe anaemia was referred to our hospital. Computed tomography (CT) demonstrated a hypervascular tumour, 17 cm in diameter, that was in the tail of the pancreas. In addition, there were multiple hypervascular tumours in the liver. She underwent a distal pancreatectomy with splenectomy after the liver metastases were treated with TACE. Pathology confirmed that the pancreatic tumour was MAEC. After 4.5 years, a follow-up CT showed a hypervascular tumour at the upper part of the stomach. Gastric endoscopy showed a big tumefactive lesion with surface irregularities, gastric erosion, and multiple dilated vessels in the fornix and greater curvature of the stomach. She underwent a proximal gastrectomy and survived 7 years and 2 months after the start of the treatment.

CONCLUSIONS: This is the first report of a metastatic stomach tumour from pancreatic MAEC, which was successfully treated with a multidisciplinary approach. Additionally, we review the literature and discuss the treatment of MAEC.

Keywords: Metastatic gastric tumour; Mixed acinar-endocrine carcinoma; Pancreatic neoplasm

References

  1. Am J Surg Pathol. 2010 Apr;34(4):510-8 - PubMed
  2. Am J Surg Pathol. 1994 Aug;18(8):765-78 - PubMed
  3. Acta Cytol. 2013;57(3):296-302 - PubMed
  4. Clin J Gastroenterol. 2013 Dec;6(6):459-64 - PubMed
  5. Am J Gastroenterol. 2008 Oct;103(10 ):2659-60 - PubMed
  6. J Korean Med Sci. 1996 Apr;11(2):188-92 - PubMed
  7. Pancreas. 2013 Apr;42(3):429-35 - PubMed
  8. Diagn Cytopathol. 2013 Feb;41(2):164-70 - PubMed
  9. Surg Today. 2010 Apr;40(4):380-4 - PubMed
  10. Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):203-9 - PubMed
  11. Rare Tumors. 2011 Apr 4;3(2):e15 - PubMed
  12. Korean J Radiol. 2010 May-Jun;11(3):378-81 - PubMed
  13. Onco Targets Ther. 2015 Jul 03;8:1633-42 - PubMed
  14. Cases J. 2009 Apr 28;2:6481 - PubMed

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