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Kılıç MÖ, Yalaza M, Bilgiç Cİ, et al. Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report. J Breast Health. 2015;11(2):95-97doi: 10.5152/tjbh.2015.1879.
Kılıç, M. �. �., Yalaza, M., Bilgiç, C. �. �., & Dener, C. (2015). Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report. The journal of breast health, 11(2), 95-97. https://doi.org/10.5152/tjbh.2015.1879
Kılıç, Murat Özgür, et al. "Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report." The journal of breast health vol. 11,2 (2015): 95-97. doi: https://doi.org/10.5152/tjbh.2015.1879
Kılıç MÖ, Yalaza M, Bilgiç Cİ, Dener C. Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report. J Breast Health. 2015 Apr 01;11(2):95-97. doi: 10.5152/tjbh.2015.1879. eCollection 2015 Apr. PMID: 28331700; PMCID: PMC5351495.
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J Breast Health. 2015 Apr 01;11(2):95-97. doi: 10.5152/tjbh.2015.1879. eCollection 2015 Apr.

Docetaxel-induced Scleroderma in A Breast Cancer Patient: A Case Report.

The journal of breast health

Murat Özgür Kılıç, Metin Yalaza, Celal İsmail Bilgiç, Cenap Dener

Affiliations

  1. Department of General Surgery, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.

PMID: 28331700 PMCID: PMC5351495 DOI: 10.5152/tjbh.2015.1879

Abstract

Paclitaxel and docetaxel are antineoplastic drugs derived from the yew tree, Taxus brevifolia. They are the members of the taxane family and act by inhibiting mitotic activity due to the suppression of microtubule depolymerization. They are used in the treatment of ovarian cancer, breast cancer, gastric cancer, small cell lung cancer, and head and neck cancer. In addition to side effects such as cardiotoxicity, neutropenia, arthralgia, and myalgia, they may also cause alopecia, urticaria, mucositis, acral erythema, pustular dermatitis, erythema multiforme, and scleroderma-like mucocutaneous lesions. Scleroderma is among the uncommon side effects of taxane antineoplastic agents. As was the case in few cases in literature, it usually begins with edematous changes in the proximal aspect of the extremities, and subsequently, sclerosis is developed in the skin. Scleroderma, which usually regresses with the discontinuation of the drug and with steroid therapy, may lead to severe contractions that require physical therapy and rehabilitation in some patients. In this paper, we presented a 60-year-old female patient in whom scleroderma developed because docetaxel chemotherapy for breast cancer because it is encountered rarely.

Keywords: Taxoids; breast cancer; scleroderma

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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