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Receptors Clin Investig. 2016;3(3). doi: 10.14800/rci.1369. Epub 2016 Jul 21.

Chronic exposure to bisphenol a impairs progesterone receptor-mediated signaling in the uterus during early pregnancy.

Receptors & clinical investigation

Quanxi Li, Juanmahel Davila, Milan K Bagchi, Indrani C Bagchi

Affiliations

  1. Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.
  2. Departments of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

PMID: 28239613 PMCID: PMC5321573 DOI: 10.14800/rci.1369

Abstract

Environmental and occupational exposure to endocrine disrupting chemicals (EDCs) is a major threat to female reproductive health. Bisphenol A (BPA), an environmental toxicant that is commonly found in polycarbonate plastics and epoxy resins, has received much attention due to its estrogenic activity and high risk of chronic exposure in human. Whereas BPA has been linked to infertility and recurrent miscarriage in women, the impact of its exposure on uterine function during early pregnancy remains unclear. In a recent publication in

Keywords: BPA; Embryo implantation; HAND2; Progesterone Receptor; Uterus

Conflict of interest statement

Conflicting interests The authors have declared that no conflict of interests exist.

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