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Yorbik Ö, Mutlu C, Özdağ MF, et al. Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder. Noro Psikiyatr Ars. 2016;53(4):321-327doi: 10.5152/npa.2016.12659.
Yorbik, �. �., Mutlu, C., Özdağ, M. F., Olgun, A., Eryilmaz, G., & Ayta, S. (2016). Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder. Noro psikiyatri arsivi, 53(4), 321-327. https://doi.org/10.5152/npa.2016.12659
Yorbik, Özgür, et al. "Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder." Noro psikiyatri arsivi vol. 53,4 (2016): 321-327. doi: https://doi.org/10.5152/npa.2016.12659
Yorbik Ö, Mutlu C, Özdağ MF, Olgun A, Eryilmaz G, Ayta S. Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder. Noro Psikiyatr Ars. 2016 Dec;53(4):321-327. doi: 10.5152/npa.2016.12659. Epub 2016 Sep 20. PMID: 28360806; PMCID: PMC5353038.
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Noro Psikiyatr Ars. 2016 Dec;53(4):321-327. doi: 10.5152/npa.2016.12659. Epub 2016 Sep 20.

Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder.

Noro psikiyatri arsivi

Özgür Yorbik, Caner Mutlu, Mehmet Fatih Özdağ, Abdullah Olgun, Gül Eryilmaz, Semih Ayta

Affiliations

  1. Department of Child and Adolescent Psychiatry, Maltepe University School of Medicine, ?stanbul, Turkey.
  2. Department of Child and Adolescent Psychiatry, Bak?rköy Prof. Dr. Mazhar Osman Psychiatric Training and Research Hospital, ?stanbul, Turkey.
  3. Department of Neurology, Gülhane Military Medical Academy Haydarpa?a Training and Research Hospital, ?stanbul, Turkey.
  4. Biogerontology Laboratory, Akdeniz University, Antalya, Turkey.
  5. Department of Psychology, Division of Psychiatry, Üsküdar University Faculty of Humanities and Social Sciences, ?stanbul, Turkey.
  6. Clinic of Pediatrics, Child Neurology Unit, Haseki Training and Research Hospital, ?stanbul, Turkey.

PMID: 28360806 PMCID: PMC5353038 DOI: 10.5152/npa.2016.12659

Abstract

INTRODUCTION: The aims of the present study were to investigate the relationship between levels of plasma copper (Cu) and ceruloplasmin (Cp) and amplitudes and latencies of P1, N2, and P3 in the parietal and frontal areas of children with attention deficit hyperactivity disorder (ADHD) as well as to compare these Cu levels and event-related potentials (ERPs) indices in controls.

METHODS: Boys (n=41) with ADHD were divided into two subgroups according to a median split of plasma Cu and Cp levels, separately. ERP indices from the parietal and frontal regions were recorded in children with ADHD and 24 normal boys (control group) using an auditory oddball paradigm.

RESULTS: Parietal P3 latency was significantly longer, and parietal P3 amplitude, frontal P3 amplitude, and frontal N2 amplitudes were smaller in children with ADHD than in controls (all p values <0.017). Parietal P1 and frontal P1 latencies were significantly shorter in the higher Cu group than in the lower Cu group (both p values <0.017). Decreased latency of parietal P1 was dependent on plasma levels of Cu (p<0.05). Frontal N2 and parietal N2 amplitudes were significantly lower in the ADHD group with lower Cp levels than in the ADHD group with higher Cp levels (both p values <0.017). Decreased frontal N2 and parietal N2 amplitudes were dependent on plasma levels of Cp (both p values <0.05).

CONCLUSION: Plasma Cu and Cp levels may have an effect on ERPs in ADHD, thus indicating the existence of effects on information processing. Cu levels may have a negative effect on the neuronal encoding of sound, whereas Cp levels may have a positive effect on the processes of cognitive control, conflict monitoring, and stimulus discrimination in children with ADHD.

Keywords: Attention deficit hyperactivity disorder; Copper; N2; P1; P3

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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