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Nagao M, Borres MP, Sugimoto M, et al. Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy. Clin Mol Allergy. 2017;15:4doi: 10.1186/s12948-017-0061-8.
Nagao, M., Borres, M. P., Sugimoto, M., Petersson, C. J., Nakayama, S., Kuwabara, Y., Masuda, S., Dykiel, P., & Fujisawa, T. (2017). Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy. Clinical and molecular allergy : CMA, 154. https://doi.org/10.1186/s12948-017-0061-8
Nagao, Mizuho, et al. "Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy." Clinical and molecular allergy : CMA vol. 15 (2017): 4. doi: https://doi.org/10.1186/s12948-017-0061-8
Nagao M, Borres MP, Sugimoto M, Petersson CJ, Nakayama S, Kuwabara Y, Masuda S, Dykiel P, Fujisawa T. Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy. Clin Mol Allergy. 2017 Mar 03;15:4. doi: 10.1186/s12948-017-0061-8. eCollection 2017. PMID: 28270741; PMCID: PMC5335719.
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Clin Mol Allergy. 2017 Mar 03;15:4. doi: 10.1186/s12948-017-0061-8. eCollection 2017.

Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.

Clinical and molecular allergy : CMA

Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel, Takao Fujisawa

Affiliations

  1. Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
  2. Thermo Fisher Scientific, Uppsala, Sweden.
  3. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  4. Thermo Fisher Scientific, Uppsala, Tokyo Japan.
  5. Department of Pediatrics, Mie National Hospital, Tsu, Mie Japan.
  6. Department of Otorhinolaryngology, Mie National Hospital, Tsu, Mie Japan.

PMID: 28270741 PMCID: PMC5335719 DOI: 10.1186/s12948-017-0061-8

Abstract

BACKGROUND: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.

METHODS: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception.

RESULTS: At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age.

CONCLUSIONS: Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization.

Keywords: Allergy; Asthma; Children; Component resolved diagnosis; Food allergy; Lipocalin; Molecular allergy diagnostics; Pet allergen components; Secretoglobin; Sensitization

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