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Ozpelit E, Akdeniz B, Sezgin D, et al. Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study. J Geriatr Cardiol. 2017;14(1):20-27doi: 10.11909/j.issn.1671-5411.2017.01.003.
Ozpelit, E., Akdeniz, B., Sezgin, D., Sevinc, C., Tertemiz, K. C., Ozpelit, M. E., Baris, M., & Baris, N. (2017). Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study. Journal of geriatric cardiology : JGC, 14(1), 20-27. https://doi.org/10.11909/j.issn.1671-5411.2017.01.003
Ozpelit, Ebru, et al. "Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study." Journal of geriatric cardiology : JGC vol. 14,1 (2017): 20-27. doi: https://doi.org/10.11909/j.issn.1671-5411.2017.01.003
Ozpelit E, Akdeniz B, Sezgin D, Sevinc C, Tertemiz KC, Ozpelit ME, Baris M, Baris N. Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study. J Geriatr Cardiol. 2017 Jan;14(1):20-27. doi: 10.11909/j.issn.1671-5411.2017.01.003. PMID: 28270838; PMCID: PMC5329729.
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J Geriatr Cardiol. 2017 Jan;14(1):20-27. doi: 10.11909/j.issn.1671-5411.2017.01.003.

Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study.

Journal of geriatric cardiology : JGC

Ebru Ozpelit, Bahri Akdeniz, Dilek Sezgin, Can Sevinc, Kemal Can Tertemiz, Mehmet Emre Ozpelit, Mustafa Baris, Nezihi Baris

Affiliations

  1. Department of Cardiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
  2. Department of Internal Medicine, Faculty of Nursing, Dokuz Eylul University, Izmir, Turkey.
  3. Department of Chest Disease, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
  4. Department of Cardiology, Medicalpark Hospital, Izmir, Turkey.
  5. Department of Radiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.

PMID: 28270838 PMCID: PMC5329729 DOI: 10.11909/j.issn.1671-5411.2017.01.003

Abstract

BACKGROUNDS: Pulmonary arterial hypertension (PAH) was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly. The aim of this study was to compare the features of elderly versus younger patients diagnosed with PAH, and to define the prognostic factors which affect their long-term survival.

METHODS: In this prospective, single center study, the clinical, echocardiographic, hemodynamic characteristics, and the outcomes of younger (18-65 years) and elderly (≥ 65 years) patients with definitive diagnosis of precapillary PAH were compared.

RESULTS: A total of 119 patients were analyzed in this study; 43 were elderly (mean age: 71.5 ± 5.5 years), while 76 were non-elderly (mean age 44.5 ± 15.2 years). During the mean follow-up duration of 26.8 ± 25.0 months, 43 deaths occurred, 17 of which were among the elderly group, with 28 among non-elderly group. Comparison of baseline parameters showed that 6 min walking distance, hemoglobin levels, pulmonary artery pressures and pulmonary vascular resistance were significantly lower; and estimated glomerular filtration rate, body mass index, E/e' and pulmonary capillary wedge pressure were significantly higher in the elderly group than in the younger group. Survival analysis demonstrated that the independent predictors of death were tricuspid plane annular systolic excursion (TAPSE; HR: 1.272, 95% CI: 1.079-1.499,

CONCLUSIONS: Our data suggest that elderly PAH patients have a unique clinical and hemodynamic profile, with totally different prognostic markers compared to younger PAH patients.

Keywords: Clinical characteristics; Prognosis; Pulmonary hypertension; The elderly

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