Display options
Cite
de la Garza RG, Morales-Garza LA, Martin-Estal I, et al. Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment. J Clin Med Res. 2017;9(4):233-247doi: 10.14740/jocmr2761w.
de la Garza, R. G., Morales-Garza, L. A., Martin-Estal, I., & Castilla-Cortazar, I. (2017). Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment. Journal of clinical medicine research, 9(4), 233-247. https://doi.org/10.14740/jocmr2761w
de la Garza, Rocio G, et al. "Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment." Journal of clinical medicine research vol. 9,4 (2017): 233-247. doi: https://doi.org/10.14740/jocmr2761w
de la Garza RG, Morales-Garza LA, Martin-Estal I, Castilla-Cortazar I. Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment. J Clin Med Res. 2017 Apr;9(4):233-247. doi: 10.14740/jocmr2761w. Epub 2017 Feb 21. PMID: 28270882; PMCID: PMC5330765.
Copy Download .nbib Format: NLM
Share it on

J Clin Med Res. 2017 Apr;9(4):233-247. doi: 10.14740/jocmr2761w. Epub 2017 Feb 21.

Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment.

Journal of clinical medicine research

Rocio G de la Garza, Luis Alonso Morales-Garza, Irene Martin-Estal, Inma Castilla-Cortazar

Affiliations

  1. Centro de Investigacion Transferencia en Salud (CITES), Escuela Nacional de Medicina, Tecnologico de Monterrey, and Institute of Liver Diseases, Hospital San Jose, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico.
  2. Centro de Investigacion Transferencia en Salud (CITES), Escuela Nacional de Medicina, Tecnologico de Monterrey, and Institute of Liver Diseases, Hospital San Jose, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico; Fundacion de Investigacion HM Hospitales, Madrid, Spain.

PMID: 28270882 PMCID: PMC5330765 DOI: 10.14740/jocmr2761w

Abstract

Cirrhosis represents the final stage of chronic liver damage, which can be due to different factors such as alcohol, metabolic syndrome with liver steatosis, autoimmune diseases, drugs, toxins, and viral infection, among others. Nowadays, cirrhosis is an important health problem and it is an increasing cause of morbidity and mortality, being the 14th most common cause of death worldwide. The physiopathological pathways that lead to fibrosis and finally cirrhosis partly depend on the etiology. Nevertheless, some common features are shared in this complex mechanism. Recently, it has been demonstrated that cirrhosis is a dynamic process that can be altered in order to delay or revert fibrosis. In addition, when cirrhosis has been established, insulin-like growth factor-1 (IGF-1) deficiency or reduced availability is a common condition, independently of the etiology of chronic liver damage that leads to cirrhosis. IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patient, increasing the vulnerability of the liver to establish an inflammatory and oxidative microenvironment with mitochondrial dysfunction. In this context, IGF-1 deficiency in cirrhotic patients can justify some of the common characteristics of these individuals. Several studies in animals and humans have been done in order to test the replacement of IGF-1 as a possible therapeutic option, with promising results.

Keywords: Acute liver damage; Fibrogenesis; GH/IGF-1 axis; IGF-1; Mitochondrial protection; Non-alcoholic fatty liver disease; Oxidative damage; Steatosis

References

  1. J Biol Chem. 2009 Jul 24;284(30):19937-44 - PubMed
  2. J Biol Chem. 2003 Apr 11;278(15):13325-32 - PubMed
  3. Annu Rev Physiol. 1985;47:443-67 - PubMed
  4. J Transl Med. 2011 Jul 28;9:123 - PubMed
  5. Apoptosis. 2011 Nov;16(11):1118-27 - PubMed
  6. J Hepatol. 2002 Jun;36(6):751-8 - PubMed
  7. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G319-24 - PubMed
  8. Gut. 2006 Sep;55(9):1306-12 - PubMed
  9. Hepatology. 1994 May;19(5):1262-71 - PubMed
  10. Gastroenterology. 1997 Nov;113(5):1617-22 - PubMed
  11. Endocrinology. 2004 Oct;145(10):4748-55 - PubMed
  12. Hepatology. 1996 Jul;24(1):127-33 - PubMed
  13. Nat Clin Pract Gastroenterol Hepatol. 2004 Dec;1(2):98-105 - PubMed
  14. N Engl J Med. 1997 Feb 27;336(9):633-40 - PubMed
  15. Zhonghua Gan Zang Bing Za Zhi. 2000 Jun;8(3):161-3 - PubMed
  16. Gastroenterology. 1997 Oct;113(4):1180-7 - PubMed
  17. Connect Tissue Res. 2007;48(3):149-58 - PubMed
  18. Eur J Endocrinol. 1994 Jul;131(1):33-40 - PubMed
  19. J Clin Endocrinol Metab. 1998 Jul;83(7):2532-8 - PubMed
  20. Acta Endocrinol (Copenh). 1992 Oct;127(4):351-8 - PubMed
  21. Clin Sci (Lond). 2009 Mar;116(6):507-12 - PubMed
  22. Mol Pathol. 2001 Oct;54(5):311-6 - PubMed
  23. BMC Med. 2014 Sep 18;12 :145 - PubMed
  24. Gene Ther. 2007 Feb;14(3):203-10 - PubMed
  25. J Clin Endocrinol Metab. 2011 Oct;96(10 ):E1640-4 - PubMed
  26. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):626-39 - PubMed
  27. J Clin Endocrinol Metab. 2000 Apr;85(4):1686-94 - PubMed
  28. Liver Int. 2011 Aug;31(7):911-9 - PubMed
  29. J Physiol Biochem. 2003 Jun;59(2):145-6 - PubMed
  30. J Hepatol. 2012 Aug;57(2):458-61 - PubMed
  31. Diabetes. 2001 May;50(5):1110-8 - PubMed
  32. Growth Horm IGF Res. 2002 Aug;12(4):193-7 - PubMed
  33. Nutrition. 1997 Mar;13(3):185-90 - PubMed
  34. Hepatology. 2010 Apr;51(4):1445-9 - PubMed
  35. World J Gastroenterol. 2008 May 7;14(17):2731-9 - PubMed
  36. Endocr Rev. 1999 Dec;20(6):761-87 - PubMed
  37. Endocrinology. 1999 Dec;140(12 ):5729-35 - PubMed
  38. World J Gastroenterol. 2014 Jun 21;20(23):7260-76 - PubMed
  39. Endocr Rev. 2008 Dec;29(7):777-822 - PubMed
  40. J Hepatol. 1998 Jan;28(1):122-31 - PubMed
  41. Am J Physiol. 1990 Oct;259(4 Pt 1):E561-7 - PubMed
  42. J Clin Endocrinol Metab. 1981 Dec;53(6):1247-50 - PubMed
  43. J Biol Chem. 2004 Jul 30;279(31):32660-6 - PubMed
  44. J Biol Chem. 1996 Nov 29;271(48):30322-5 - PubMed
  45. Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):203-7 - PubMed
  46. J Clin Endocrinol Metab. 1999 Mar;84(3):1096-103 - PubMed
  47. J Clin Invest. 2005 Feb;115(2):209-18 - PubMed
  48. Endocrinology. 2006 Jun;147(6):2619-30 - PubMed
  49. Endocrinology. 2004 Oct;145(10):4667-76 - PubMed
  50. J Hepatol. 2009 Mar;50(3):604-20 - PubMed
  51. Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1479-84 - PubMed
  52. BMC Gastroenterol. 2005 Mar 03;5:7 - PubMed
  53. Brain Behav Immun. 2007 May;21(4):384-92 - PubMed
  54. Rev Esp Enferm Dig. 2007 Mar;99(3):156-64 - PubMed
  55. Biochem Pharmacol. 1990 Sep 1;40(5):1015-9 - PubMed
  56. Hepatology. 1998 Sep;28(3):695-9 - PubMed
  57. J Hepatol. 1997 Jan;26(1):191-202 - PubMed
  58. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):629-36 - PubMed
  59. Gastroenterology. 2002 May;122(5):1525-8 - PubMed
  60. Endocrinology. 2008 May;149(5):2620-7 - PubMed
  61. J Endocrinol. 1992 Oct;135(1):59-67 - PubMed
  62. Hepatology. 2010 Mar;51(3):912-21 - PubMed
  63. Eur J Endocrinol. 2009 Nov;161(5):705-13 - PubMed
  64. J Hepatol. 2005 Oct;43(4):630-6 - PubMed
  65. Clin Gastroenterol Hepatol. 2005 Feb;3(2):95-107 - PubMed
  66. Endocrinology. 1994 Jun;134(6):2404-9 - PubMed
  67. Metab Syndr Relat Disord. 2006 Spring;4(1):51-6 - PubMed
  68. Hepatology. 2004 Jun;39(6):1647-54 - PubMed
  69. J Immunol. 2000 Aug 1;165(3):1331-6 - PubMed
  70. BMC Gastroenterol. 2004 Jun 14;4:12 - PubMed
  71. J Endocrinol Invest. 1991 Apr;14(4):317-21 - PubMed
  72. Pflugers Arch. 1996 Jul;432(3):419-25 - PubMed
  73. Toxicol Pathol. 2011 Apr;39(3):524-43 - PubMed
  74. J Hepatol. 2005;42 Suppl(1):S22-36 - PubMed
  75. Endocrinology. 1988 Jan;122(1):325-32 - PubMed
  76. Am J Physiol. 1997 Dec;273(6 Pt 1):E1189-93 - PubMed
  77. Clin Endocrinol (Oxf). 1995 Sep;43(3):265-75 - PubMed
  78. Bull World Health Organ. 1977;55(4):521-40 - PubMed
  79. Acta Gastroenterol Latinoam. 2012 Mar;42(1):20-6 - PubMed
  80. Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112 - PubMed
  81. Genes Dev. 2001 Aug 1;15(15):1926-34 - PubMed
  82. Biochim Biophys Acta. 2001 May 31;1536(2-3):185-95 - PubMed
  83. Dev Biol. 1980 Mar 15;75(2):315-28 - PubMed
  84. Immunology. 2002 Dec;107(4):461-71 - PubMed
  85. J Hepatol. 1996 Nov;25(5):689-99 - PubMed
  86. Gastroenterology. 2003 Jan;124(1):105-17 - PubMed
  87. Metab Syndr Relat Disord. 2012 Feb;10(1):3-13 - PubMed
  88. J Clin Invest. 1993 Oct;92(4):1903-9 - PubMed
  89. Endocr Rev. 1995 Feb;16(1):3-34 - PubMed
  90. Endocr Rev. 2002 Dec;23(6):824-54 - PubMed
  91. Hepatology. 1995 May;21(5):1238-47 - PubMed
  92. Acta Endocrinol (Copenh). 1993 Feb;128(2):144-9 - PubMed
  93. Endocrinol Metab Clin North Am. 2004 Jun;33(2):351-75, table of contents - PubMed
  94. Biochem Biophys Res Commun. 2012 Jun 29;423(2):295-300 - PubMed
  95. J Transl Med. 2015 Oct 14;13:326 - PubMed
  96. Physiol Res. 2008;57(6):919-25 - PubMed
  97. Int J Biochem Cell Biol. 2002 Mar;34(3):242-52 - PubMed
  98. J Hepatol. 1997 Nov;27(5):796-802 - PubMed
  99. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7088-92 - PubMed
  100. Ugeskr Laeger. 1997 Jul 21;159(30):4636-40 - PubMed
  101. Hepatology. 1995 Mar;21(3):680-8 - PubMed
  102. Hepatology. 2000 Apr;31(4):851-7 - PubMed
  103. Am J Clin Pathol. 2012 Jan;137(1):5-9 - PubMed
  104. FASEB J. 2006 Apr;20(6):773-5 - PubMed
  105. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12981-6 - PubMed
  106. Endocrinology. 2008 May;149(5):2433-42 - PubMed
  107. Ann Intern Med. 1997 Dec 1;127(11):981-5 - PubMed
  108. Lancet. 2014 May 17;383(9930):1749-61 - PubMed
  109. Lancet. 2008 Mar 8;371(9615):838-51 - PubMed
  110. Am J Gastroenterol. 1997 May;92(5):777-83 - PubMed
  111. Zhonghua Gan Zang Bing Za Zhi. 2001 Jul;9 Suppl:76-8 - PubMed
  112. J Physiol Biochem. 2001 Mar;57(1):59-60 - PubMed
  113. Gastroenterology. 1997 Nov;113(5):1682-91 - PubMed
  114. Am J Physiol. 1999 Jan;276(1 Pt 1):G37-42 - PubMed
  115. J Hepatol. 1997 Dec;27(6):1133-8 - PubMed
  116. Cell Transplant. 2002;11(5):399-402 - PubMed
  117. Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1360-8 - PubMed
  118. Gastroenterology. 2003 Feb;124(2):568-71 - PubMed
  119. Hepatology. 2004 Jun;39(6):1477-87 - PubMed
  120. J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S5-10 - PubMed
  121. Endocr J. 2012;59(11):955-62 - PubMed
  122. Hepatology. 2015 Mar;61(3):1066-79 - PubMed
  123. Liver. 2001 Dec;21(6):405-9 - PubMed
  124. Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52 - PubMed
  125. Int J Endocrinol. 2014;2014:235060 - PubMed
  126. J Clin Invest. 1989 May;83(5):1717-23 - PubMed
  127. Cancer Res. 1996 Aug 15;56(16):3831-6 - PubMed
  128. Hepatology. 2000 Mar;31(3):592-600 - PubMed
  129. Genes Dev. 1993 Dec;7(12B):2609-17 - PubMed
  130. J Transl Med. 2016 Jan 06;14 :3 - PubMed
  131. Gastroenterology. 2002 May;122(5):1303-13 - PubMed
  132. World J Gastroenterol. 2006 Jun 28;12(24):3821-8 - PubMed
  133. Semin Cell Dev Biol. 2002 Dec;13(6):439-46 - PubMed
  134. Liver Int. 2009 Jan;29(1):37-46 - PubMed
  135. Hepatology. 1990 Jan;11(1):123-6 - PubMed
  136. Endocr Dev. 2005;9:121-34 - PubMed
  137. Hepatology. 2003 Dec;38(6):1552-62 - PubMed

Publication Types