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Stuart S, Benton MC, Eccles DA, et al. Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility. Mol Genet Genomic Med. 2017;5(2):157-163doi: 10.1002/mgg3.270.
Stuart, S., Benton, M. C., Eccles, D. A., Sutherland, H. G., Haupt, L. M., Lea, R. A., & Griffiths, L. R. (2017). Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility. Molecular genetics & genomic medicine, 5(2), 157-163. https://doi.org/10.1002/mgg3.270
Stuart, Shani, et al. "Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility." Molecular genetics & genomic medicine vol. 5,2 (2017): 157-163. doi: https://doi.org/10.1002/mgg3.270
Stuart S, Benton MC, Eccles DA, Sutherland HG, Haupt LM, Lea RA, Griffiths LR. Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility. Mol Genet Genomic Med. 2017 Jan 17;5(2):157-163. doi: 10.1002/mgg3.270. eCollection 2017 Mar. PMID: 28361102; PMCID: PMC5370233.
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Mol Genet Genomic Med. 2017 Jan 17;5(2):157-163. doi: 10.1002/mgg3.270. eCollection 2017 Mar.

Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.

Molecular genetics & genomic medicine

Shani Stuart, Miles C Benton, David A Eccles, Heidi G Sutherland, Larisa M Haupt, Rodney A Lea, Lyn R Griffiths

Affiliations

  1. Genomics Research Centre Institute for Biomedical Health and Innovation School of Biomedical Sciences Queensland University of Technology Brisbane Queensland 4059 Australia.

PMID: 28361102 PMCID: PMC5370233 DOI: 10.1002/mgg3.270

Abstract

BACKGROUND: Migraine is a common neurological disorder which affects a large proportion of the population. The Norfolk Island population is a genetically isolated population and is an ideal discovery cohort for genetic variants involved in complex disease susceptibility given the reduced genetic and environmental heterogeneity. Given that the majority of proteins responsible for mitochondrial function are nuclear encoded, this study aimed to investigate the role of Nuclear Encoded Mitochondrial Protein (NEMP) genes in relation to migraine susceptibility.

METHODS: A gene-centric association analysis of NEMP genes was undertaken in the most related individuals (

RESULTS: The discovery phase of the study implicated SNPs in 5 NEMP genes to be associated with migraine susceptibility (

CONCLUSION: Here we provide evidence that variation in NEMP genes is associated with migraine susceptibility. This study provides evidence for a link between mitochondrial function and migraine susceptibility.

Keywords: Complex disease; Norfolk Island; gene centric; migraine; mitochondrial dysfunction; neurogenetics; nuclear encoded mitochondrial protein genes

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