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Ratre MS, Mehta DS. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016;20(4):396-401doi: 10.4103/0972-124X.194271.
Ratre, M. S., & Mehta, D. S. (2016). Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. Journal of Indian Society of Periodontology, 20(4), 396-401. https://doi.org/10.4103/0972-124X.194271
Ratre, Madhu Singh, and Mehta, Dhoom Singh. "Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats." Journal of Indian Society of Periodontology vol. 20,4 (2016): 396-401. doi: https://doi.org/10.4103/0972-124X.194271
Ratre MS, Mehta DS. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. doi: 10.4103/0972-124X.194271. PMID: 28298821; PMCID: PMC5341314.
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J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. doi: 10.4103/0972-124X.194271.

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats.

Journal of Indian Society of Periodontology

Madhu Singh Ratre, Dhoom Singh Mehta

Affiliations

  1. Department of Periodontology, Government College of Dentistry, Indore, Madhya Pradesh, India.
  2. Department of Periodontology, Bapuji Dental College and Hospital, Davangere, Karnataka, India.

PMID: 28298821 PMCID: PMC5341314 DOI: 10.4103/0972-124X.194271

Abstract

BACKGROUND: Drug-induced gingival overgrowth (DIGO) is a well-known adverse effect of cyclosporine A (CsA) and nifedipine (Nf) therapy. The aim of the present morphometric study was to evaluate the effect of azithromycin (Azi) on the combined GO in rats induced by CsA + Nf combination.

MATERIALS AND METHODS: Thirty Sprague-Dawley male rats were randomly divided equally into three groups. Group 1 (control) received olive oil only; Group 2 received a combination of CsA and Nf in olive oil throughout the study period; Group 3 received CsA + Nf combination therapy, and Azi was added for 1 week in the 5

RESULTS: Significant GO was evident in Group 2 and Group 3 rats when compared to Group 1. However, in Group 3 (Azi), GO was observed up to the 4

CONCLUSION: Azi is an effective drug in the remission of DIGO induced by combined therapy of CsA + Nf and thereby can be considered as a useful therapeutic regimen in minimizing the DIGO in transplant patients.

Keywords: Animal; azithromycin; cyclosporine; gingival overgrowth; model; nifedipine

Conflict of interest statement

There are no conflicts of interest.

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