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Stieg MR, Renner U, Stalla GK, et al. Advances in understanding hypopituitarism. F1000Res. 2017;6:178doi: 10.12688/f1000research.9436.1.
Stieg, M. R., Renner, U., Stalla, G. K., & Kopczak, A. (2017). Advances in understanding hypopituitarism. F1000Research, 6178. https://doi.org/10.12688/f1000research.9436.1
Stieg, Mareike R, et al. "Advances in understanding hypopituitarism." F1000Research vol. 6 (2017): 178. doi: https://doi.org/10.12688/f1000research.9436.1
Stieg MR, Renner U, Stalla GK, Kopczak A. Advances in understanding hypopituitarism. F1000Res. 2017 Feb 22;6:178. doi: 10.12688/f1000research.9436.1. eCollection 2017. PMID: 28299199; PMCID: PMC5325066.
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F1000Res. 2017 Feb 22;6:178. doi: 10.12688/f1000research.9436.1. eCollection 2017.

Advances in understanding hypopituitarism.

F1000Research

Mareike R Stieg, Ulrich Renner, Günter K Stalla, Anna Kopczak

Affiliations

  1. Max Planck Institute of Psychiatry, Clinical Neuroendocrinology, Kraepelinstr. 2-10, D-80804 Munich, Germany.

PMID: 28299199 PMCID: PMC5325066 DOI: 10.12688/f1000research.9436.1

Abstract

The understanding of hypopituitarism has increased over the last three years. This review provides an overview of the most important recent findings. Most of the recent research in hypopituitarism has focused on genetics. New diagnostic techniques like next-generation sequencing have led to the description of different genetic mutations causative for congenital dysfunction of the pituitary gland while new molecular mechanisms underlying pituitary ontogenesis have also been described. Furthermore, hypopituitarism may occur because of an impairment of the distinctive vascularization of the pituitary gland, especially by disruption of the long vessel connection between the hypothalamus and the pituitary. Controversial findings have been published on post-traumatic hypopituitarism. Moreover, autoimmunity has been discussed in recent years as a possible reason for hypopituitarism. With the use of new drugs such as ipilimumab, hypopituitarism as a side effect of pharmaceuticals has come into focus. Besides new findings on the pathomechanism of hypopituitarism, there are new diagnostic tools in development, such as new growth hormone stimulants that are currently being tested in clinical trials. Moreover, cortisol measurement in scalp hair is a promising tool for monitoring cortisol levels over time.

Keywords: Sheehan`s syndrome; combined pituitary hormone deficiency; hypopituitarism; isolated growth hormone deficiency; post-traumatic hypopituitarism; vascularization

Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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