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Gonzalez-Vicente A, Garvin JL. Effects of Reactive Oxygen Species on Tubular Transport along the Nephron. Antioxidants (Basel). 2017;6(2)doi: 10.3390/antiox6020023.
Gonzalez-Vicente, A., & Garvin, J. L. (2017). Effects of Reactive Oxygen Species on Tubular Transport along the Nephron. Antioxidants (Basel, Switzerland), 6(2), . https://doi.org/10.3390/antiox6020023
Gonzalez-Vicente, Agustin, and Garvin, Jeffrey L. "Effects of Reactive Oxygen Species on Tubular Transport along the Nephron." Antioxidants (Basel, Switzerland) vol. 6,2 (2017). doi: https://doi.org/10.3390/antiox6020023
Gonzalez-Vicente A, Garvin JL. Effects of Reactive Oxygen Species on Tubular Transport along the Nephron. Antioxidants (Basel). 2017 Mar 23;6(2). doi: 10.3390/antiox6020023. PMID: 28333068; PMCID: PMC5488003.
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Antioxidants (Basel). 2017 Mar 23;6(2). doi: 10.3390/antiox6020023.

Effects of Reactive Oxygen Species on Tubular Transport along the Nephron.

Antioxidants (Basel, Switzerland)

Agustin Gonzalez-Vicente, Jeffrey L Garvin

Affiliations

  1. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].
  2. Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina. [email protected].
  3. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. [email protected].

PMID: 28333068 PMCID: PMC5488003 DOI: 10.3390/antiox6020023

Abstract

Reactive oxygen species (ROS) are oxygen-containing molecules naturally occurring in both inorganic and biological chemical systems. Due to their high reactivity and potentially damaging effects to biomolecules, cells express a battery of enzymes to rapidly metabolize them to innocuous intermediaries. Initially, ROS were considered by biologists as dangerous byproducts of respiration capable of causing oxidative stress, a condition in which overproduction of ROS leads to a reduction in protective molecules and enzymes and consequent damage to lipids, proteins, and DNA. In fact, ROS are used by immune systems to kill virus and bacteria, causing inflammation and local tissue damage. Today, we know that the functions of ROS are not so limited, and that they also act as signaling molecules mediating processes as diverse as gene expression, mechanosensation, and epithelial transport. In the kidney, ROS such as nitric oxide (NO), superoxide (O₂

Keywords: epithelial transport; renal physiology; salt-sensitive hypertension; water homeostasis

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