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Uji A, Abdelfattah NS, Boyer DS, et al. Variability of Retinal Thickness Measurements in Tilted or Stretched Optical Coherence Tomography Images. Transl Vis Sci Technol. 2017;6(2):1doi: 10.1167/tvst.6.2.1.
Uji, A., Abdelfattah, N. S., Boyer, D. S., Balasubramanian, S., Lei, J., & Sadda, S. R. (2017). Variability of Retinal Thickness Measurements in Tilted or Stretched Optical Coherence Tomography Images. Translational vision science & technology, 6(2), 1. https://doi.org/10.1167/tvst.6.2.1
Uji, Akihito, et al. "Variability of Retinal Thickness Measurements in Tilted or Stretched Optical Coherence Tomography Images." Translational vision science & technology vol. 6,2 (2017): 1. doi: https://doi.org/10.1167/tvst.6.2.1
Uji A, Abdelfattah NS, Boyer DS, Balasubramanian S, Lei J, Sadda SR. Variability of Retinal Thickness Measurements in Tilted or Stretched Optical Coherence Tomography Images. Transl Vis Sci Technol. 2017 Mar 01;6(2):1. doi: 10.1167/tvst.6.2.1. eCollection 2017 Mar. PMID: 28299239; PMCID: PMC5347660.
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Transl Vis Sci Technol. 2017 Mar 01;6(2):1. doi: 10.1167/tvst.6.2.1. eCollection 2017 Mar.

Variability of Retinal Thickness Measurements in Tilted or Stretched Optical Coherence Tomography Images.

Translational vision science & technology

Akihito Uji, Nizar Saleh Abdelfattah, David S Boyer, Siva Balasubramanian, Jianqin Lei, SriniVas R Sadda

Affiliations

  1. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA ; Department of Ophthalmology, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California, USA.
  2. Retina Vitreous Associates Medical Group, Beverly Hills, California, USA.
  3. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA ; Department of Ophthalmology, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California, USA ; Retina Vitreous Associates Medical Group, Beverly Hills, California, USA.

PMID: 28299239 PMCID: PMC5347660 DOI: 10.1167/tvst.6.2.1

Abstract

PURPOSE: To investigate the level of inaccuracy of retinal thickness measurements in tilted and axially stretched optical coherence tomography (OCT) images.

METHODS: A consecutive series of 50 eyes of 50 patients with age-related macular degeneration were included in this study, and Cirrus HD-OCT images through the foveal center were used for the analysis. The foveal thickness was measured in three ways: (1) parallel to the orientation of the A-scan (Tx), (2) perpendicular to the retinal pigment epithelium (RPE) surface in the instrument-displayed aspect ratio image (Ty), and (3) thickness measured perpendicular to the RPE surface in a native aspect ratio image (Tz). Mathematical modeling was performed to estimate the measurement error.

RESULTS: The measurement error was larger in tilted images with a greater angle of tilt. In the simulation, with axial stretching by a factor of 2, Ty/Tz ratio was > 1.05 at a tilt angle between 13° to 18° and 72° to 77°, > 1.10 at a tilt angle between 19° to 31° and 59° to 71°, and > 1.20 at an angle ranging from 32° to 58°. Of note with even more axial stretching, the Ty/Tz ratio is even larger. Tx/Tz ratio was smaller than the Ty/Tz ratio at angles ranging from 0° to 54°. The actual patient data showed good agreement with the simulation.

The Ty/Tz ratio was greater than 1.05 (5% error) at angles ranging from 13° to 18° and 72° to 77°, greater than 1.10 (10% error) angles ranging from 19° to 31° and 59° to 71°, and greater than 1.20 (20% error) angles ranging from 32° to 58° in the images axially stretched by a factor of 2 (b/a = 2), which is typical of most OCT instrument displays.

CONCLUSIONS: Retinal thickness measurements obtained perpendicular to the RPE surface were overestimated when using tilted and axially stretched OCT images.

TRANSLATIONAL RELEVANCE: If accurate measurements are to be obtained, images with a native aspect ratio similar to microscopy must be used.

Keywords: optical coherence tomography; retina; retinal thickness

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