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Sfera A, Osorio C, Inderias LA, et al. The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients. Front Psychiatry. 2017;8:20doi: 10.3389/fpsyt.2017.00020.
Sfera, A., Osorio, C., Inderias, L. A., Parker, V., Price, A. I., & Cummings, M. (2017). The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients. Frontiers in psychiatry, 820. https://doi.org/10.3389/fpsyt.2017.00020
Sfera, Adonis, et al. "The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients." Frontiers in psychiatry vol. 8 (2017): 20. doi: https://doi.org/10.3389/fpsyt.2017.00020
Sfera A, Osorio C, Inderias LA, Parker V, Price AI, Cummings M. The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients. Front Psychiatry. 2017 Feb 13;8:20. doi: 10.3389/fpsyt.2017.00020. eCollection 2017. PMID: 28243210; PMCID: PMC5303716.
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Front Psychiatry. 2017 Feb 13;8:20. doi: 10.3389/fpsyt.2017.00020. eCollection 2017.

The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

Frontiers in psychiatry

Adonis Sfera, Carolina Osorio, Luzmin Acosta Inderias, Victoria Parker, Amy I Price, Michael Cummings

Affiliations

  1. Patton State Hospital, Psychiatry , Patton, CA , USA.
  2. Loma Linda University, Psychiatry , Loma Linda, CA , USA.
  3. Patton State Hospital, Medicine , Patton, CA , USA.
  4. Patton State Hospital, Dietary , Patton, CA , USA.
  5. Oxford University, Evidence Based Medicine , Oxford , UK.

PMID: 28243210 PMCID: PMC5303716 DOI: 10.3389/fpsyt.2017.00020

Abstract

Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals with mental illness even in the absence of exposure to psychotropic drugs. As the overlapping neurobiology of impulsivity and obesity is being unraveled, the question asked louder and louder is whether they should be treated concomitantly. The treatment of obesity and metabolic dysregulations in chronic psychiatric patients is currently underutilized and often initiated late, making correction more difficult to achieve. Addressing obesity and metabolic dysfunction in a preventive manner may not only lower morbidity and mortality but also the excessive impulsivity, decreasing the risk for aggression. In this review, we take a look beyond psychopharmacological interventions and discuss dietary and physical therapy approaches.

Keywords: acetylcholine; impulsivity; microbiome; monoamines; short-chain fatty acids

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