Display options
Cite
Woodward MR, Amrutkar CV, Shah HC, et al. Validation of olfactory deficit as a biomarker of Alzheimer disease. Neurol Clin Pract. 2017;7(1):5-14doi: 10.1212/CPJ.0000000000000293.
Woodward, M. R., Amrutkar, C. V., Shah, H. C., Benedict, R. H., Rajakrishnan, S., Doody, R. S., Yan, L., & Szigeti, K. (2017). Validation of olfactory deficit as a biomarker of Alzheimer disease. Neurology. Clinical practice, 7(1), 5-14. https://doi.org/10.1212/CPJ.0000000000000293
Woodward, Matthew R, et al. "Validation of olfactory deficit as a biomarker of Alzheimer disease." Neurology. Clinical practice vol. 7,1 (2017): 5-14. doi: https://doi.org/10.1212/CPJ.0000000000000293
Woodward MR, Amrutkar CV, Shah HC, Benedict RH, Rajakrishnan S, Doody RS, Yan L, Szigeti K. Validation of olfactory deficit as a biomarker of Alzheimer disease. Neurol Clin Pract. 2017 Feb;7(1):5-14. doi: 10.1212/CPJ.0000000000000293. PMID: 28243501; PMCID: PMC5310210.
Copy Download .nbib Format: NLM
Share it on

Neurol Clin Pract. 2017 Feb;7(1):5-14. doi: 10.1212/CPJ.0000000000000293.

Validation of olfactory deficit as a biomarker of Alzheimer disease.

Neurology. Clinical practice

Matthew R Woodward, Chaitanya V Amrutkar, Harshit C Shah, Ralph H B Benedict, Sanjanaa Rajakrishnan, Rachelle S Doody, Li Yan, Kinga Szigeti

Affiliations

  1. Alzheimer's Disease and Memory Disorders Center, Department of Neurology (MRW, CVA, HCS, RHBB, SR, KS), and Department of Bioinformatics (LY), University at Buffalo, SUNY, NY; and Alzheimer's Disease and Memory Disorders Center (RSD), Department of Neurology, Baylor College of Medicine, Houston, TX.

PMID: 28243501 PMCID: PMC5310210 DOI: 10.1212/CPJ.0000000000000293

Abstract

BACKGROUND: We evaluated smell identification as a biomarker for Alzheimer disease (AD) by assessing its utility in differentiating normal aging from an amnestic disorder and determining its predictive value for conversion from amnestic mild cognitive impairment (aMCI) to AD.

METHODS: Cross-sectional study (AD = 262, aMCI = 110, controls = 194) measuring smell identification (University of Pennsylvania Smell Identification Test [UPSIT]) and cognitive status was performed, as well as longitudinal analysis of aMCI participants (n = 96) with at least 1 year follow-up (mean 477.6 ± 223.3 days), to determine conversion by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria.

RESULTS: Odor identification and disease status were highly correlated after correcting for age, sex, and

CONCLUSIONS: Olfactory identification deficit is a useful screening tool for AD-related amnestic disorder, with sensitivity and specificity comparable to other established biomarkers, with benefits such as ease of administration and low cost. Olfactory identification deficit can be utilized to stratify risk of conversion from aMCI to AD and enrich clinical trials of disease-modifying therapy.

CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that smell identification (10-item UPSIT subset) accurately identifies patients with amnestic disorders.

References

  1. Rev Esp Geriatr Gerontol. 2011 Oct;46 Suppl 1:47-54 - PubMed
  2. Neurology. 2011 Apr 12;76(15):1302-9 - PubMed
  3. Ann Neurol. 2005 Jul;58(1):155-60 - PubMed
  4. Int J Neurosci. 1989 Dec;49(3-4):157-97 - PubMed
  5. J Am Osteopath Assoc. 2010 Sep;110(9 Suppl 8):S37-42 - PubMed
  6. Int J Clin Pract. 2012 Feb;66(2):185-98 - PubMed
  7. Neurology. 2001 May 8;56(9):1143-53 - PubMed
  8. Cochrane Database Syst Rev. 2014 Jun 10;(6):CD008782 - PubMed
  9. Am J Psychiatry. 2000 Sep;157(9):1399-405 - PubMed
  10. Health Aff (Millwood). 1993 Summer;12(2):164-76 - PubMed
  11. Neurology. 1993 Nov;43(11):2412-4 - PubMed
  12. Arch Neurol. 1999 Mar;56(3):303-8 - PubMed
  13. Dialogues Clin Neurosci. 2003 Mar;5(1):89-99 - PubMed
  14. Am J Psychiatry. 2003 Nov;160(11):1995-2002 - PubMed
  15. J Geriatr Psychiatry Neurol. 2010 Sep;23 (3):185-98 - PubMed
  16. J Alzheimers Dis. 2011;26(4):627-45 - PubMed
  17. Neurobiol Aging. 2012 Jul;33(7):1203-14 - PubMed
  18. Biol Psychiatry. 2008 Nov 15;64(10):871-9 - PubMed
  19. Adv Otorhinolaryngol. 2006;63:84-98 - PubMed
  20. Arch Neurol. 1994 Dec;51(12):1198-204 - PubMed
  21. Laryngoscope. 1984 Feb;94(2 Pt 1):176-8 - PubMed
  22. Gerontologist. 1969 Autumn;9(3):179-86 - PubMed
  23. Alzheimers Dement. 2014 Jul;10 (4):421-9.e3 - PubMed
  24. Arch Neurol. 2008 Aug;65(8):1091-5 - PubMed
  25. Chem Senses. 2010 Nov;35(9):855-62 - PubMed
  26. Acta Neuropathol. 1987;73(4):365-9 - PubMed
  27. Neurology. 1999 Oct 22;53(7):1480-7 - PubMed
  28. J Psychiatr Res. 1982-1983;17(1):37-49 - PubMed
  29. Arch Neurol. 2002 Nov;59(11):1737-46 - PubMed
  30. J Am Geriatr Soc. 2008 Aug;56(8):1517-21 - PubMed

Publication Types